Inhaled delivery of 23-valent pneumococcal polysaccharide vaccine does not result in enhanced pulmonary mucosal immunoglobulin responses.

Vaccine
Stephen B GordonNeil French

Abstract

We compared the effect of intramuscular vs. inhaled 23-valent pneumococcal capsular polysaccharide vaccine (23-PPV) on pulmonary mucosal immunoglobulin levels. Bronchoalveolar lavage (BAL) and serum were collected from 33 adults before and 1 month after injected (n=16) or inhaled (n=17) 23-PPV. Levels of pneumococcal capsule-specific IgG and IgA to types 1, 9V and 14 were measured in each sample. Injected 23-PPV produced a significant increase in types 1, 9V and 14 capsule-specific IgG and type 1 IgA in both serum and BAL (type 1 geometric mean BAL IgG 9.8 ng/ml post-vaccine vs. 5 ng/ml pre-vaccine, p=0.01; type 9V geo mean 5.6 ng/ml vs. 2.7 ng/ml, p=0.001; type 14 geo mean 23.6 ng/ml vs. 6.2 ng/ml, p=0.02). Inhaled vaccine produced no response in either BAL or serum.

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Citations

Sep 17, 2014·American Journal of Respiratory and Critical Care Medicine·Kondwani C JamboHenry C Mwandumba
Aug 4, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Wouter F TonnisJean-Pierre Amorij
Jun 22, 2013·Expert Opinion on Drug Delivery·Wouter F TonnisWouter L J Hinrichs
Jul 26, 2011·Trends in Microbiology·Daniela M FerreiraStephen B Gordon
Aug 6, 2011·Respiratory Medicine·Georgia G Pitsiou, Ioannis P Kioumis
Nov 12, 2010·Tuberculosis·David A Hokey, Amit Misra
Dec 30, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Antoni PayerasMa Carmen Gallegos
Jul 16, 2019·Expert Review of Vaccines·Viviane Maimoni GonçalvesEliane Namie Miyaji
Jun 24, 2021·The Journal of Infectious Diseases·Elena MitsiD M Ferreira

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Methods Mentioned

BETA
X-ray
bronchoalveolar lavage
ELISA
bronchoalveolar
lavage

Software Mentioned

Stata8
Stata

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