PMID: 11050259Oct 26, 2000

Inhaled disodium cromoglycate (DSCG) as maintenance therapy in children with asthma: a systematic review

Marjolein J A TascheJohannes C van der Wouden


Disodium cromoglycate (DSCG) is included in the BTS guidelines on the treatment of asthma for use in children, but is now used only infrequently. We have identified and interpreted the findings of all published randomised, placebo controlled trials of DSCG in the prophylactic treatment of children with asthma. Several databases were searched to identify trials. Studies were included if they investigated subjects with asthma aged 0-18 years old, addressed maintenance treatment with inhaled DSCG, and were published in English. The methodological quality of the studies was assessed independently by three reviewers. The 95% confidence intervals (CI) of differences in the treatment effect for cough and wheeze between placebo and treatment with DSCG were computed. The estimates were pooled and tested for homogeneity and, to assess possible publication bias, a funnel plot was made and tested for symmetry. Of the 24 randomised, placebo controlled trials identified, the methodological scores varied widely. The null hypothesis of homogeneity was rejected. Under the assumption of heterogeneity the overall CI for wheeze was 0.11 to 0.26 and for cough was 0.13 to 0.27. The overall tolerance intervals (-0.11 to 0. 48 and -0.04 to 0.43 for wh...Continue Reading


Nov 1, 1977·Archives of Disease in Childhood·E J HillerW Lenney
Apr 1, 1975·British Journal of Diseases of the Chest·E J Hiller, A D Milner
Dec 11, 1975·The New England Journal of Medicine·A L ShefferE J Goetzl
Jan 1, 1990·Pediatric Pulmonology·H P Van BeverW J Stevens
May 1, 1989·Respiratory Medicine·J O Warner
Dec 1, 1987·Controlled Clinical Trials·K DickersinH Smith
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 1, 1985·Archives of Disease in Childhood·J J Cogswell, M J Simpkiss
Aug 12, 1974·JAMA : the Journal of the American Medical Association·J CrispW C Deamer
Sep 1, 1974·American Journal of Diseases of Children·M B Marks
Aug 12, 1972·British Medical Journal·M SilvermanS Godfrey
May 11, 1968·British Medical Journal·J M Smith, G F Devey
Jan 1, 1984·Archives of Disease in Childhood·R L HenryG M Stokes
Dec 1, 1983·Annals of Internal Medicine·S Ahmad
Aug 1, 1981·Archives of Disease in Childhood·J GlassH Simpson
Jan 1, 1982·Respiration; International Review of Thoracic Diseases·C Geller-Bernstein, S Levin
May 1, 1981·Controlled Clinical Trials·T C ChalmersA Ambroz
Sep 9, 1995·BMJ : British Medical Journal·J O Warner
Aug 19, 1995·BMJ : British Medical Journal·A W Robins, B W Lloyd
Mar 25, 1995·BMJ : British Medical Journal·M Egger, G D Smith
Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
Jul 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M Edwards
Oct 1, 1994·Archives of Disease in Childhood·S FurfaroM Robert
Sep 3, 1994·BMJ : British Medical Journal·C D Mulrow
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Aug 1, 1996·Respiratory Medicine·S T Holgate
May 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R M Sly
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 24, 1997·The Journal of Allergy and Clinical Immunology·C CalpinP C Parkin
Jan 7, 1998·Clinical Pediatrics·M R Lester, D L Bratton


Oct 3, 2002·Current Allergy and Asthma Reports·Marianna Sockrider
Aug 9, 2005·Journal of Clinical Epidemiology·Norma TerrinJoseph Lau
Feb 6, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Samy Suissa
Jul 25, 2003·Pulmonary Pharmacology & Therapeutics·Gaetano Caramori, Ian Adcock
Oct 10, 2002·Allergy·Johan C de JongsteJohannes C van der Wouden
Oct 19, 2004·The Nurse Practitioner·Kevin R MurphyNancy L Sarver
Feb 13, 2001·Archives of Disease in Childhood·C V PowellC F Robertson
Sep 16, 2006·BMJ : British Medical Journal·Joseph LauIngram Olkin
Dec 14, 2004·American Journal of Respiratory and Critical Care Medicine·Alejandro Manuel TeperAlberto F Maffey
Mar 22, 2005·American Journal of Respiratory and Critical Care Medicine·Eric K Chu, Jeffrey M Drazen
Mar 13, 2002·Paediatric Drugs·Elizabeth Biggart, Andrew Bush
Sep 27, 2003·Paediatric Drugs·David Coghlan, Colin Powell
Oct 10, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M Edwards, J B Howell
May 4, 2006·Current Opinion in Allergy and Clinical Immunology·Alejandro Manuel Teper, Carlos Daniel Kofman
Aug 27, 2013·Current Opinion in Allergy and Clinical Immunology·Punchama Pacharn, Pakit Vichyanond
May 19, 2011·European Journal of Pharmacology·Léonidas BizumukamaFrédéric Cotton
Nov 3, 2009·Paediatric Respiratory Reviews·Bart L Rottier, Eric J Duiverman
Jun 24, 2003·Statistics in Medicine·Norma TerrinIngram Olkin
Mar 12, 2003·Pediatric Pulmonology·Athanasios G KaditisGlenna Winnie
Mar 20, 2004·Pediatric Pulmonology. Supplement·Andrew Bush
May 30, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Chih-Hsing HungYu-Te Chu
Mar 17, 2007·Pharmaceutical Statistics·M T StevensJ B L Howell
May 30, 2007·Pharmaceutical Statistics·M T StevensJ B L Howell
Nov 9, 2006·Advances in Pediatrics·Henry Milgrom
Apr 19, 2002·Paediatric Drugs·John Massie
May 16, 2015·The World Allergy Organization Journal·Noriyuki YanagidaMotohiro Ebisawa
Nov 2, 2013·Clinical Reviews in Allergy & Immunology·T E AlbertsonS Louie
Jun 6, 2006·The Journal of International Medical Research·R González-SánchezA Elizalde
Dec 8, 2004·Clinical Pediatrics·Nemr S Eid, National Asthma Education and Prevention Program
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Johannes C van der WoudenFrancine Ducharme
May 10, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Peter J Helms
Mar 27, 2002·The Medical Journal of Australia·P van Asperen PeterThoracic Society of Australia and New Zealand
Oct 2, 2019·Disease-a-month : DM·Roua AzmehRobert D Lloyd
Sep 13, 2002·The Medical Journal of Australia·Peter P Van Asperen

Related Concepts

Inhalation of Drugs
Data Interpretation, Statistical
Meta Analysis (Statistical Procedure)
Anti-Asthmatic Agents

Related Feeds


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.