Inhaled epinephrine for the treatment of transient tachypnea of the newborn

Journal of Perinatology : Official Journal of the California Perinatal Association
B KaoA Hansen

Abstract

Infants with transient tachypnea of the newborn (TTN) have relatively low levels of epinephrine, which is known to mediate fetal lung fluid absorption. Providing exogenous epinephrine could be a valuable diagnostic and therapeutic intervention for this common condition. Our primary objective was to determine if inhaled racemic epinephrine is safe for the treatment of TTN. Our secondary objective was to determine its efficacy. We conducted a randomized, blinded, placebo-controlled pilot trial. Inhaled racemic epinephrine or placebo was administered to 20 newborns with TTN. Physiologic variables of cardiopulmonary function were measured during and after treatment. No infant in either the treatment or control arm experienced an adverse event, including tachycardia or hypertension. We did not detect a difference between the two groups regarding rate of resolution of tachypnea. We did not observe any adverse effects of inhaled racemic epinephrine when administered for the treatment of TTN. Larger studies are necessary to determine efficacy.

References

Mar 1, 1978·Pediatric Research·D V Walters, R E Olver
Aug 1, 1979·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L CaberoJ Esteban-Altirriba
Sep 1, 1976·American Journal of Obstetrics and Gynecology·M HackI R Merkatz
Jan 1, 1992·Journal of Perinatal Medicine·A Greenough, H Lagercrantz
Jul 15, 1985·American Journal of Obstetrics and Gynecology·C K Heritage, M D Cunningham
Apr 1, 1966·American Journal of Diseases of Children·M E AveryG Brumley
Jul 1, 1984·AJR. American Journal of Roentgenology·P J HaneyC C Sun
Jan 1, 1983·Biology of the Neonate·D M PatelW J Keenan
Jan 1, 1984·Acta Obstetricia Et Gynecologica Scandinavica·T F Nielsen, K H Hökegård
Feb 1, 1995·British Journal of Obstetrics and Gynaecology·J J MorrisonP J Milton
Oct 1, 1993·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K A HalesG R Thurnau
May 5, 2000·The Cochrane Database of Systematic Reviews·M W Davies, P G Davis
Jan 1, 1996·Indian Journal of Pediatrics·A Kumar, B V Bhat
Mar 10, 2001·Obstetrics and Gynecology·E M LevineC M Strom
May 2, 2001·The Cochrane Database of Systematic Reviews·M W Davies, P G Davis
Mar 1, 2002·The Cochrane Database of Systematic Reviews·M W Davies, P G Davis
Sep 18, 2002·Journal of Applied Physiology·Pierre M Barker, Richard E Olver
Feb 20, 2004·The Cochrane Database of Systematic Reviews·L HartlingT P Klassen
Dec 18, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Reese H Clark
Jan 27, 2005·American Journal of Obstetrics and Gynecology·Bryan S RichardsonRenato Natale
Mar 22, 2006·Seminars in Perinatology·Lucky Jain, Douglas C Eaton

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Citations

Nov 4, 2008·Pediatrics in Review·Lokesh GuglaniRita M Ryan
Apr 13, 2011·The Journal of Pediatrics·Didem ArmangilGülsevin Tekinalp
Aug 16, 2011·The Journal of Pediatrics·Annemarie StroustrupIan R Holzman
Jun 24, 2016·Global Pediatric Health·Esengul KeleşAlparslan Tonbul
May 24, 2016·The Cochrane Database of Systematic Reviews·Luca MorescoMatteo Bruschettini
Sep 25, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Akinobu TaniguchiSeiji Hayashi
Aug 23, 2018·Journal of the Chinese Medical Association : JCMA·Arash MalakianSolmaz Heidari
May 8, 2010·International Urology and Nephrology·Tom Cornelis, Dimitrios G Oreopoulos
Aug 6, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Ziad AlhassenRita M Ryan
Sep 3, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Murat Yurdakök
Oct 21, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ashok BuchiboyinaSanjay Patole
Feb 19, 2021·The Cochrane Database of Systematic Reviews·Neeraj GuptaDeepak Chawla

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