Inhaled epoprostenol therapy for pulmonary hypertension: Improves oxygenation index more consistently in neonates than in older children.

Pulmonary Circulation
Anna T BrownLewis H Romer

Abstract

The purpose of this study was to determine the efficacy of inhaled epoprostenol for treatment of acute pulmonary hypertension (PH) in pediatric patients and to formulate a plan for a prospective, randomized study of pulmonary vasodilator therapy in this population. Inhaled epoprostenol is an effective treatment for pediatric PH. A retrospective chart review was conducted of all pediatric patients who received inhaled epoprostenol at a tertiary care hospital between October 2005 and August 2007. The study population was restricted to all patients under 18 years of age who received inhaled epoprostenol for greater than 1 hour and had available data for oxygenation index (OI) calculation. Arterial blood gas values and ventilator settings were collected immediately prior to epoprostenol initiation, and during epoprostenol therapy (as close to 12 hours after initiation as possible). Echocardiograms were reviewed during two time frames: Within 48 hours prior to therapy initiation and within 96 hours after initiation. Of the 20 patients in the study population, 13 were neonates, and the mean OI for these patients improved during epoprostenol administration (mean OI before and during therapy was 25.6±16.3 and 14.5±13.6, respectively, P...Continue Reading

References

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Citations

Mar 29, 2014·Pediatric Allergy, Immunology, and Pulmonology·Christopher D BakerPeter M Mourani
Jul 11, 2012·Pediatric Pulmonology·Joseph M CollacoSharon A McGrath-Morrow
May 11, 2016·Pulmonary Circulation·Robert M DiBlasiDelphine Yung
Mar 9, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Anne Greenough, Niovi Papalexopoulou
Aug 22, 2015·Therapeutic Advances in Respiratory Disease·Randi J SearcyDonald W Johnson
Aug 13, 2013·Dimensions of Critical Care Nursing : DCCN·Angela Arumpanayil
Jul 27, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Kaashif Aqeeb AhmadGeorge Charles Powers

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