Inhaled furosemide in hospitalized infants with viral bronchiolitis: a randomized, double-blind, placebo-controlled pilot study

Pediatric Pulmonology
Amir BarAmir Kugelman

Abstract

To evaluate the short and long-term clinical effects and the treatment-feasibility of inhaled-furosemide (IF) as compared with placebo via hood in hospitalized infants with viral-bronchiolitis (VB). A randomized, double-blind, placebo-controlled pilot-study was performed in previously healthy infants (0-12 months). Enrolled infants were randomized to receive either IF (2 mg/kg), or placebo nebulized by hood three times daily throughout the hospitalization. Clinical assessment (respiratory distress assessment instrument [RDAI]) was performed before, 30 and 60 min after the 1st daily inhalation. The short-term effects were evaluated by the RDAI, respiratory assessment change score (RACS) and oxygen requirement and the long-term effects by time to be weaned off oxygen, time to full enteral feeding, length of stay, and "ready to discharge" time. Both groups (16 infants each) had comparable characteristics at study entry. Mean (+/-SD) age was 72 +/- 43 days, and 29/32 infants were RSV positive. Oxygen requirement (FiO(2)) decreased significantly at 30 min post-inhalation (30 +/- 9.2% to 26 +/- 7.1%, P < 0.05) only in the IF group. RACSs and long-term effects of both groups were comparable. Analysis of IF particles generated by the h...Continue Reading

References

Oct 1, 1978·The American Review of Respiratory Disease·M E Wohl, V Chernick
Sep 1, 1978·Critical Care Medicine·R H Demling, J A Will
Nov 1, 1992·The American Review of Respiratory Disease·E L StevensK T Nakamura
Feb 1, 1992·Archives of Disease in Childhood·J SeidenbergH von der Hardt
Dec 1, 1991·Journal of Applied Physiology·J Solway, A R Leff
May 1, 1991·The Journal of Pediatrics·T P KlassenM M Li
Feb 1, 1990·Pediatric Research·D GozalZ Hochberg
Oct 19, 1989·The New England Journal of Medicine·S BiancoP Sestini
May 31, 1969·British Medical Journal·M L BhatiaS B Roy
Jul 1, 1995·Pediatric Pulmonology·H P Van BeverP A Vermeire
Dec 1, 1994·The Journal of Pediatrics·A RastogiR S Pildes
Jan 1, 1997·Respiration; International Review of Thoracic Diseases·T TanigakiY Ohta
Jul 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·V G PrabhuR Dhanireddy
Oct 27, 1999·JAMA : the Journal of the American Medical Association·D K ShayL J Anderson
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·T NishinoJ Sato
Sep 28, 2000·Journal of Applied Physiology·M R CorbozA E Taylor
Jul 4, 2003·The New England Journal of Medicine·Claire WainwrightPaul Francis
Jul 24, 2003·Archives of Disease in Childhood·I AmiravA S Luder
Feb 24, 2004·American Journal of Respiratory and Critical Care Medicine·Kian-Chung OngYee-Tang Wang
Aug 6, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Karen G SchüeppJohannes H Wildhaber
Nov 18, 2005·The Journal of Pediatrics·Israel AmiravAvigdor Mandelberg
Dec 13, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·A KugelmanD Bader
Oct 4, 2006·Pediatrics·UNKNOWN American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis

❮ Previous
Next ❯

Citations

Nov 14, 2013·Indian Pediatrics·Nishant VermaS K Kabra
Jan 13, 2010·Clinical Microbiology Reviews·John S Tregoning, Jürgen Schwarze
Jul 3, 2013·Early Human Development·Liviana Da DaltEugenio Baraldi
Mar 30, 2010·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J González de DiosUNKNOWN Grupo de Revisión del Proyecto aBREVIADo (BRonquiolitis-Estudio de Variabilidad, Idoneidad y Adecuación)
Aug 29, 2014·European Journal of Pediatrics·S GalA Kugelman
Nov 28, 2013·Pharmaceuticals·Gian Maria Pacifici

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved