PMID: 20647692Jul 22, 2010Paper

Inhaled magnesium fluoride reverse bronchospasma

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
Fedoua GandiaZouhair Tabka

Abstract

Asthma is a global health problem. Asthma attacks are becoming more severe and more resistant to usual treatment by beta(2) agonists nebulisation. The search for a new product that could reduce the morbidity of asthmatic disease seems necessary. The objective of this study was to compare the effectiveness of inhaled magnesium fluoride (MgF(2)) with that of magnesium sulphate (MgSO(4)) 15% alone and sodium fluoride (NaF) 0.5 M alone in rats pre-contracted by methacholine (MeCh). Fifty six adult male Wistar rats of medium weight 259 +/- 15 g were divided randomly into five groups. They inhaled respectively: MeCh, MgF(2) + NaCl 0.9%, MgF(2) + acetic acid, MgSO(4) 15% single and NaF (0.5 M) single. Airway resistances were measured after each dose of MeCh by pneumomultitest equipment. Results indicated that (1) MgF(2) + NaCl 0.9%, MgF(2) + acetic acid and MgSO(4) reversed significantly the methacholine-induced bronchial constriction in rats and had a bronchodilating effect at the moment of its administration (2) MgF(2) + acetic acid led to a greater decrease (P<0.05) of bronchial resistances when compared to that obtained from MgF(2) + NaCl 0.9%, NaF exclusively and MgSO(4) alone (3) inhaled NaF alone led to a significant bronchorel...Continue Reading

References

Jan 1, 1981·The Science of the Total Environment·H SpencerM Lender
Jan 1, 1994·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S K SharmaJ N Pande
Dec 1, 1996·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·C B Cairns, M Kraft
May 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J HillJ Britton
Oct 20, 1998·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M HarariJ Shani
May 5, 2000·The Cochrane Database of Systematic Reviews·B H RoweC A Camargo
Nov 6, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·K I GourgoulianisP A Molyvdas
Jun 1, 2002·Lung·N L Stephens
Jul 20, 2002·Respiratory Physiology & Neurobiology·Weimin ZhaoHervé Guénard

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Citations

Aug 26, 2017·Environmental Science and Pollution Research International·Jaishabanu Ameeramja, Ekambaram Perumal

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