PMID: 9190553Jun 1, 1997Paper

Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia. The Neonatal Inhaled Nitric Oxide Study Group (NINOS)

Pediatrics

Abstract

We designed and conducted a randomized, double-masked, controlled multicenter study to determine whether inhaled nitric oxide (INO) in term and near-term infants with congenital diaphragmatic hernia (CDH) would reduce the occurrence of death and/or the initiation of extracorporeal membrane oxygenation (ECMO). Infants of 34 weeks gestation or more, <14 days of age with CDH, without known structural heart disease, requiring assisted ventilation for hypoxemic respiratory failure with two oxygenation indices (OIs) of 25 or more at least 15 minutes apart, were eligible for this trial. Infants were centrally randomized and then received masked treatment with 20 ppm NO or 100% oxygen as control. Infants with less than a full response to 20 ppm NO (increase in PaO2 > 20 Torr) after 30 minutes were evaluated at 80 ppm NO/control study gas. The 28 control and 25 treated infants enrolled by the 13 participating centers were not significantly different at randomization for any of the measured variables including prerandomization therapies and initial OIs (45.8 +/- 16.3 for controls, 44.5 +/- 14.5 for INO). Death at <120 days of age or the need for ECMO occurred in 82% of control infants compared with 96% of INO infants (ns). Death occurred...Continue Reading

Citations

Nov 2, 2007·Pediatric Surgery International·Geraldine Yin Taeng NgSandra Adamson Calvert
Nov 6, 2008·Pediatric Surgery International·Tadaharu OkazakiAtsuyuki Yamataka
Oct 24, 2012·Pediatric Surgery International·Massimo GarriboliAgostino Pierro
Jun 10, 2010·Indian Journal of Pediatrics·V JainV Bhatnagar
Aug 2, 2003·Journal of Pediatric Surgery·Amir KugelmanManuel Durand
Jul 8, 1998·Pediatric Clinics of North America·M C McGettiganJ P Goldsmith
Feb 9, 2000·Pharmacology & Therapeutics·B WeinbergerJ D Laskin
Mar 18, 1999·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·B ThébaudF Beaufils
Mar 6, 2004·Seminars in Neonatology : SN·Cynthia D Downard, Jay M Wilson
Oct 28, 2004·The Kaohsiung Journal of Medical Sciences·Hung-Te HsuChao-Shun Tang
Feb 24, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·N YamaguchiR Higuchi
Jun 1, 2000·The New England Journal of Medicine·N S Adzick, M L Nance
Dec 4, 2004·International Anesthesiology Clinics·Hiromasa Kawakami, Fumito Ichinose
Jun 1, 1999·Current Opinion in Pediatrics·M R Hemmila, R B Hirschl
Jun 3, 2000·Current Opinion in Pediatrics·J Gnanaratnem, N N Finer
Jul 20, 2002·Current Opinion in Pediatrics·Ronald B Hirschl
Apr 12, 2003·Critical Care Medicine·Udo KaisersKonrad J Falke
Feb 28, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Roberta L KellerSamuel Hawgood
Apr 10, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Amerik C de MolKian D Liem
Sep 26, 2006·Annals of Surgery·Kevin P LallyUNKNOWN Congenital Diaphragmatic Hernia Study Group
Apr 12, 2012·Current Opinion in Pediatrics·Michael D Rollins
Nov 8, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Patrick J McNamaraAnna Taddio
Apr 25, 2006·Journal of Paediatrics and Child Health·Peter M FilanLara S Shekerdemian
Nov 3, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·C F Davis, A J Sabharwal
Nov 25, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nikesh R LathDouglas A Potoka
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Desmond Bohn
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Bernard ThébaudA Tuan Dinh-Xuan
Nov 1, 2000·Critical Care : the Official Journal of the Critical Care Forum·S Al-Alaiyan, E Neiley
Apr 1, 2012·Journal of Clinical Neonatology·Martin Keszler
Oct 3, 2013·Early Human Development·Robin H Steinhorn
Jul 27, 2014·Pediatric Surgery International·Julio Alejandro Rojas-MoscosoLourenço Sbragia
Dec 3, 2014·Seminars in Fetal & Neonatal Medicine·Enrico Danzer, Holly L Hedrick
Dec 3, 2014·Seminars in Fetal & Neonatal Medicine·M Pierro, B Thébaud
Jan 30, 2002·Seminars in Pediatric Surgery·Martin L Blakely, Kevin P Lally
Mar 7, 2003·Pediatric Research·John J GreerBernard Thebaud
Jul 20, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·J W LoganC M Cotten

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.