PMID: 9420103Jan 7, 1998Paper

Inhaled nitric oxide in acute respiratory distress syndrome

The Journal of Trauma
J A JohannigmanR D Branson

Abstract

Inhaled nitric oxide has been shown to improve oxygenation in select patients with acute respiratory distress syndrome (ARDS). The purpose of this study was to evaluate the clinical response to four concentrations of inhaled nitric oxide (NO) in 20 patients with ARDS. All patients with ARDS were eligible for the study. ARDS was defined as (1) the presence of a predisposing factor; (2) a PaO2/FiO2 ratio < 200; (3) bilateral infiltrates on chest radiograph; and (4) absence of evidence of congestive heart failure and pulmonary artery wedge pressure < 18 mm Hg. Patients received each of four doses (1, 15, 30, and 60 ppm) in random order, each for a 3-hour period. Cardiovascular variables were continuously monitored, and arterial and mixed venous blood gas measurements were obtained at 30 minutes and 3 hours. Thirteen of the 20 patients demonstrated a significant increase in their PaO2/FiO2 (> 20% increase) when treated with inhaled NO. The administration of inhaled NO was associated with an increase in oxygenation at doses of 1, 15, and 30 ppm, but not 60 ppm. Increasing NO dose to more than 1 ppm did not significantly improve response. Mean pulmonary artery pressure decreased with increasing NO concentration, but this did not reac...Continue Reading

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Citations

Jul 4, 2001·Journal of Clinical Anesthesia·A R SolinaT J Krause
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·D T Efron, A Barbul
Mar 26, 2002·Critical Care Clinics·Jean-Louis Vincent
Sep 23, 2003·Anesthesia and Analgesia·Jennifer SokolDesmond Bohn
Jun 28, 2016·The Cochrane Database of Systematic Reviews·Fabienne GebistorfArash Afshari
Jun 19, 2019·Journal of Intensive Care Medicine·Shawn KakuWare G Kuschner
Aug 27, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·José R FiorettoMário F Carpi

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