PMID: 9551741Apr 29, 1998Paper

Inhaled nitric oxide in hypoxaemic newborns who are candidates for extracorporeal life support

The European Respiratory Journal
P BibanF Zacchello

Abstract

The aim of this study was to evaluate the effect of inhaled nitric oxide (NO) in newborns with acute hypoxaemic respiratory failure and the impact of this NO therapy on survival and the need for extracorporeal membrane oxygenation (ECMO). A cohort of newborns with a gestational age of > or = 34 weeks and an oxygenation index (OI) > 25 were prospectively evaluated. Patients were given NO at an initial dose of 10 parts per million (ppm). Oxygenation parameters were evaluated prior and during NO inhalation. From January 1994 to December 1996, 20 infants were enrolled in the study. Based upon their outcome, patients were divided into two groups: survivors with no need for ECMO, group A (n=8) and survivors requiring ECMO or nonsurvivors, group B (n=12). All infants approached or met ECMO criteria before NO inhalation. Eight patients (40%) were successfully managed with NO and conventional treatment (group A). Newborns in this group showed a rapid and sustained improvement of systemic oxygenation during NO inhalation. Mean arterial oxygen tension (Pa,O2) increased significantly from 4.5 kPa (34 mmHg) (95% confidence interval (95% CI) 1.9-7.1 kPa (14.4-53.7 mmHg)) to 10.1 kPa (75.7 mmHg) (95% CI 6.5-13.6 kPa (49.1-1023 mmHg)) after 1 ...Continue Reading

Citations

Feb 9, 2000·Pharmacology & Therapeutics·B WeinbergerJ D Laskin
Jun 27, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·E W CoatesT M O'Shea
Nov 4, 2000·Expert Opinion on Investigational Drugs·A Greenough
Oct 29, 2005·Journal of Critical Care·Robert P Jankov, Patrick J McNamara

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