PMID: 9535459Apr 16, 1998Paper

Inhaled nitric oxide is not a myocardial depressant in a porcine model of heart failure

The Journal of Thoracic and Cardiovascular Surgery
M ArgenzianoM L Dickstein

Abstract

Inhaled nitric oxide has been shown to be a potent and selective pulmonary vasodilator. Reports of increases in left ventricular end-diastolic pressure and episodes of pulmonary edema during the clinical use of inhaled nitric oxide in patients with preexisting left ventricular dysfunction have raised concerns that this agent may have myocardial depressant effects. We therefore undertook a study of the effects of inhaled nitric oxide on myocardial contractility in a porcine model of ventricular failure and pulmonary hypertension. After inducing heart failure in 10 pigs by rapid ventricular pacing, hemodynamic measurements and pressure-volume diagrams (by the conductance method) were obtained in six animals at baseline and during administration of inhaled nitric oxide at concentrations of 20 and 40 ppm. Myocardial contractile state was assessed by the end-systolic pressure-volume relationship and preload-recruitable stroke work, whereas diastolic function was measured in terms of the end-diastolic pressure-volume relationship and the pressure decay time constant T. Baseline hemodynamics reflected heart failure and pulmonary hypertension, and inhaled nitric oxide induced significant reductions in mean pulmonary artery pressure and...Continue Reading

References

Sep 1, 1984·Annals of Internal Medicine·G S FrancisJ N Cohn
Apr 1, 1995·Annals of Surgery·T R Billiar
Oct 1, 1994·Journal of the American College of Cardiology·M J SemigranM A Fifer
Jul 1, 1994·The American Journal of Cardiology·E A BocchiF Pileggi
Jul 15, 1993·The New England Journal of Medicine·M MonchiA T Dinh-Xuan
Feb 1, 1993·Circulation·J D RobertsW M Zapol
May 1, 1993·The Annals of Thoracic Surgery·H KomaiY Kawashima
May 1, 1993·Trends in Cardiovascular Medicine·A M Shah, M J Lewis

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Citations

Nov 5, 1999·Journal of Cardiovascular Pharmacology·C S HaywardR P Kelly
Apr 16, 2014·Annals of Cardiac Anaesthesia·Vishal GargSteven Stamenkovic
Jul 6, 2000·The Annals of Thoracic Surgery·M Argenziano, M L Dickstein
Aug 18, 2004·Journal of the American College of Cardiology·Ignacio InglessisMarc J Semigran
Aug 7, 2010·Journal of Applied Physiology·Alberto PagnamentaRobert Naeije

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