PMID: 8957365Dec 1, 1996Paper

Inhaled nitric oxide reveals and attenuates endothelial dysfunction after lung transplantation

The Annals of Thoracic Surgery
L LindbergS Steen

Abstract

Maintaining endothelial function within transplanted organs may be critical to successful preservation. In this study we have evaluated the relationship between the effect of inhalation of nitric oxide and the degree of endothelial dysfunction after lung transplantation. A left lung, which had been preserved for 24 hours, was transplanted and a right pneumonectomy was performed in 5 pigs. After a 24-hour observation period the pigs inhaled 5, 20, and 80 ppm nitric oxide, and pulmonary vascular resistance was recorded continuously. From the same donors preserved pulmonary arteries from the contralateral lung were studied simultaneously in organ baths. Acetylcholine chloride was used to elicit endothelium-dependent relaxation in vessel segments contracted with the thromboxane A2 analogue U-46619. Maximal endothelium-dependent relaxation decreased in the preserved lungs and correlated to the pulmonary vascular resistance in the simultaneously transplanted lungs. Inhalation of nitric oxide in the pigs that had received transplants caused the pulmonary vessels to dilate in proportion to the endothelial dysfunction. Preservation of lung for transplantation induces an endothelial dysfunction, and the degree of the decrease in pulmonar...Continue Reading

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Citations

Jul 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R BolysS Steen
Jun 26, 2007·The Annals of Thoracic Surgery·Leo M GazoniIrving L Kron
Apr 24, 1999·The Annals of Thoracic Surgery·L T ErikssonS Steen
Jul 19, 2015·Nitric Oxide : Biology and Chemistry·Maria BenedettoNandor Marczin
Mar 27, 2001·Lancet·S SteenL Algotsson
Dec 22, 1999·The Journal of Surgical Research·S P LuhY C Lee
Oct 3, 2006·Current Opinion in Anaesthesiology·J BriegelM Haller

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