Inhaled nitric oxide to improve oxygenation for safe critical care transport of adults with severe hypoxemia

American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses
Nicholas R TemanLena M Napolitano

Abstract

Inhaled nitric oxide (iNO) is a rescue treatment for severe hypoxemia in the intensive care unit setting. To evaluate the effectiveness and safety of iNO in adult patients with severe hypoxemia before and during transport to a tertiary care center. Prospective data were examined in a retrospective cohort study. Patients with severe hypoxemia and cardiopulmonary failure (n=139) at referring hospitals in whom conventional therapy was unsuccessful were treated with iNO in the intensive care units in anticipation of transfer to a tertiary center. Treatment wih iNO was initiated by the critical care transport team in 114 patients and continued in 25 patients. Arterial blood gas analysis was done before and after iNO treatment. Patients treated with iNO had significant improvement in oxygenation: mean (SD) for PaO2 increased from 60.7 (20.2) to 72.3 (40.6) mm Hg (P=.008), and mean (SD) for ratio of PaO2 to fraction of inspired oxygen (P:F) increased from 62.4 (26.1) to 73.1 (42.6) (P= .03). Use of iNO was continued through transport in 102 patients, all of whom were transported without complication. The P:F continued to improve, with a mean (SD) of 109.7 (73.8) from 6 to 8 hours after arrival at the tertiary center (P< .001 relative ...Continue Reading

Citations

Nov 30, 2016·Current Opinion in Critical Care·Onnen MoererMichael Quintel
Sep 15, 2016·Journal of Intensive Care Medicine·Susan R WilcoxSharon DeGrace
Oct 11, 2017·Current Opinion in Critical Care·Thomas Piraino, Eddy Fan
Jan 10, 2018·Pediatric Pulmonology·Richard D BransonDario Rodriquez
May 6, 2020·American Journal of Respiratory and Critical Care Medicine·Roham T ZamanianVinicio de Jesus Perez
Mar 4, 2020·NeoReviews·Jason GienJohn P Kinsella
Aug 13, 2020·British Journal of Pharmacology·Valentina CitiVincenzo Calderone
Mar 6, 2021·Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace·Nicola Barbarito
May 27, 2021·Critical Care Research and Practice·Leonid KoyfmanEvgeni Brotfain

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