Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Z N MirzaA Morikawa

Abstract

Beta2-adrenoceptor agonists (beta2-agonists) are shown to inhibit airway microvascular leakage in experimental animals. This effect may change in animals with chronic airway inflammation. We examined whether inhaled beta2-agonists inhibit microvascular leakage in guinea-pig airways with chronic allergic inflammation. Three weeks after the sensitization with ovalbumin (OA; 6 mg/mL), each guinea pig was challenged with inhaled OA once a day for 1 or 3 weeks. Control animals without sensitization with OA also inhaled vehicle for OA (saline) for 3 weeks. One day after the last challenge, different doses of inhaled procaterol (1, 3 or 10 microg/mL) or vehicle was given to animals for 10 min after an anaesthesia. Fifteen minutes after the end of inhalation, the animals were given i.v. Evans blue dye (EB dye; 20 mg/kg), a marker of microvascular leakage, and then i.v. histamine (3 or 30 microg/kg) or vehicle. Lung resistance, a parameter of airflow obstruction, was measured for 6 min and the lungs were removed to calculate the amount of extravasated EB dye into the airways. A significant increase in eosinophil infiltration into the airways was seen in sensitized and challenged animals compared with control animals without sensitizatio...Continue Reading

References

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Citations

Nov 28, 2002·Clinical and Experimental Immunology·A TachibanaA Morikawa
Oct 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G W VolcheckH Kita
Jun 10, 2011·International Archives of Allergy and Immunology·Yukiko HiraguchiTakao Fujisawa
Mar 9, 2002·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Takao FujisawaHitoshi Kamiya
May 25, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Zafar Nazir MirzaAkihiro Morikawa

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