Inhaled prostacyclin (PGI2) is an effective addition to the treatment of pulmonary hypertension and hypoxia in the operating room and intensive care unit

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Manon HachéJ G Guimond

Abstract

There is a growing interest in the intraoperative and intensive care use of inhaled epoprostenol (PGI2) for the treatment of pulmonary hypertension (PHT) and hypoxia of cardiac or non-cardiac origin. We report our experience with this form of therapy. A retrospective chart review of all patients who received inhaled PGI2 over a one-year period was undertaken. Demographic, hemodynamic, oxygenation status, mode of administration, side effects, duration of hospital stay, and mortality were noted. Thirty-five patients, of which 33 (92%) were in the intensive care unit, received inhaled PGI2. Of the 27 patients whose pulmonary artery pressure (PAP) was monitored, a significant decrease in mean PAP from 34.8 +/- 11.8 mmHg to 32.1 +/- 11.8 mmHg was observed within one hour after the start of therapy (P=0.0017). Selective pulmonary vasodilatation occurred in 77.8% of the patients. Thirty-three patients had arterial blood gases before and after therapy. There was an improvement in the PaO2/FIO2 ratio in 88% of these with a 175% improvement on average. The ratio of PaO2/FIO2 improved from 108 +/- 8 to 138 +/- 105 (P=0.001). Six patients (17%) presented hypotension, two had subsequent pneumothorax, one had bronchospasm and in one patient ...Continue Reading

References

Jun 29, 1978·Nature·S MoncadaJ R Vane
Apr 1, 1988·Journal of Applied Physiology·C C HardyS T Holgate
Feb 1, 1985·Critical Care Medicine·N R MacIntyreR E Coleman
Jan 1, 1984·Respiration; International Review of Thoracic Diseases·O C BurghuberC Leithner
Mar 1, 1995·American Journal of Respiratory and Critical Care Medicine·D WalmrathW Seeger
Jan 1, 1993·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M WelteK Messmer
May 1, 1996·Annals of Internal Medicine·H OlschewskiW Seeger
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·B ZwisslerK Peter
May 1, 1997·The European Respiratory Journal·D WalmrathW Seeger
Aug 1, 1997·Anaesthesia and Intensive Care·P V van HeerdenN Michalopoulos
Sep 26, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E TroncyG Blaise
Jul 11, 1998·Critical Care Medicine·M KleenB Zwissler
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·H OlschewskiW Seeger

❮ Previous
Next ❯

Citations

Nov 7, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kassiani TheodorakiTheophani Antoniou
Sep 15, 2007·Critical Care Medicine·Roham T ZamanianAnn B Weinacker
Sep 23, 2010·Critical Care : the Official Journal of the Critical Care Forum·Laura C PriceStephen J Brett
Jul 16, 2005·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Nancy McLaughlinAndré Denault
Oct 10, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Danja S GrovesJohn A Kern
Oct 24, 2012·Anesthesiology Clinics·Jens Lohser
Jan 12, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mehmet Emin OzdoganMustafa Buyukates
Jun 26, 2010·Pharmacotherapy·Mitchell S Buckley, Jeremy P Feldman
Jun 22, 2010·Cardiovascular Therapeutics·Gan Hui-li
Oct 26, 2012·Anesthesiology Research and Practice·Jochen GilleArmin Sablotzki
Dec 3, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Maxime LaflammeAndré Y Denault
May 31, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Kathirvel Subramaniam, Jean-Pierre Yared
Nov 26, 2003·Anesthesiology·Gilbert BlaiseBernard Hubert
Dec 25, 2003·Anesthesia and Analgesia·André MartineauAndré Denault
Dec 17, 2009·European Journal of Anaesthesiology·Yee Wei Teo, Donna L Greenhalgh
Dec 14, 2012·Current Opinion in Anaesthesiology·André Yvan DenaultAlain Deschamps
Apr 9, 2014·Journal of Cardiovascular Pharmacology·Julie W ChengRichard A Krasuski
Jan 23, 2013·Current Opinion in Cardiology·Bhagat PatlollaFrancois Haddad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.