Inhaled prostacyclin reduces cardiopulmonary bypass-induced pulmonary endothelial dysfunction via increased cyclic adenosine monophosphate levels

The Journal of Thoracic and Cardiovascular Surgery
S FortierL P Perrault

Abstract

Cardiopulmonary bypass triggers a systemic inflammatory response that alters pulmonary endothelial function, which can contribute to pulmonary hypertension. This study was designed to demonstrate that inhaled prostacyclin, a selective pulmonary vasodilator prostaglandin, prevents pulmonary arterial endothelial dysfunction induced by cardiopulmonary bypass. Three groups of Landrace swine were compared: control without cardiopulmonary bypass (control group); 90 minutes of normothermic cardiopulmonary bypass (bypass group); 90 minutes of cardiopulmonary bypass and treated with prostacyclin during cardiopulmonary bypass (continuous nebulization with continuous positive airway pressure until the end of the cardiopulmonary bypass; prostacyclin group). After 60 minutes of reperfusion, swine were put to death and pulmonary arteries harvested. After contraction to phenylephrine, endothelium-dependent relaxation to bradykinin and acetylcholine was studied in standard organ chamber experiments. The pulmonary artery intravascular cyclic adenosine monophosphate content was compared between the 3 groups (post-cardiopulmonary bypass). There was a statistically significant improvement of the endothelium-dependent relaxation to bradykinin in th...Continue Reading

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Citations

Jul 16, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Juan Carlos BiancoAndré Y Denault
Nov 21, 2013·The Journal of Thoracic and Cardiovascular Surgery·Tongyun ChenJianshi Liu
Jun 10, 2011·The Canadian Journal of Cardiology·Tsvetomir LoukanovMatthias Gorenflo
Nov 14, 2006·Acta Anaesthesiologica Scandinavica·M JormalainenJ Petäjä
Feb 10, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Mohammed M MinhajAndrew Maslow
Jun 6, 2006·Journal of Cardiothoracic and Vascular Anesthesia·Arnaud RobitailleRaymond Martineau
Jul 7, 2005·The Journal of Thoracic and Cardiovascular Surgery·Y LamarcheL P Perrault
Dec 3, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Maxime LaflammeAndré Y Denault
Nov 18, 2015·Oxidative Medicine and Cellular Longevity·Emad Al JaalyGianni D Angelini
Jan 4, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·André Y DenaultLouis P Perrault
Jun 23, 2006·Anesthesia and Analgesia·Andrew D MaslowArun K Singh

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