Inhaled sodium cromoglycate for asthma in children

The Cochrane Database of Systematic Reviews
J C van der WoudenF M Ducharme

Abstract

Sodium cromoglycate has been recommended as maintenance treatment for childhood asthma for many years. Its use has decreased since 1990, when inhaled corticosteroids became popular, but it is still used in many countries. To determine the efficacy of sodium cromoglycate compared to placebo in the prophylactic treatment of children with asthma. We searched the Cochrane Airways Group Trials Register (October 2007), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library Issue 3, 2007), MEDLINE (January 1966 to November 2007), EMBASE (January 1985 to November 2007) and reference lists of articles. We also contacted the pharmaceutical company manufacturing sodium cromoglycate. In 2007 we updated the review. All double-blind, placebo-controlled randomised trials, which addressed the effectiveness of inhaled sodium cromoglycate as maintenance therapy, studying children aged 0 up to 18 years with asthma. Two authors independently assessed trial quality and extracted data. We pooled study results. Of 3500 titles retrieved from the literature, 24 papers reporting on 23 studies could be included in the review. The studies were published between 1970 and 1997 and together included 1026 participants. Most were cr...Continue Reading

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Related Concepts

Asthma
Vicrom
Controlled Clinical Trials, Randomized
Anti-Asthmatic Agents
Adrenal Cortex Hormones
Asthma
Bronchodilator Agents
Cromolyn Sodium
Double-Blind Method
Literature

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