Inhaled vancomycin-induced allergic reaction in decontamination of respiratory tracts for allogeneic bone marrow transplantation

Bone Marrow Transplantation
K KahataM Asaka

Abstract

A 34-year-old male suffered from an allergic reaction after inhalation of decontaminating drugs for BMT. Clinical challenge tests were undertaken to determine the causal drug. It was found that vancomycin hydrochloride (VCM) repeatedly induced dyspnea, fever, hypoxia, eosinophilia, and elevation of CRP. Therefore, clindamycin (CLDM) was used instead of VCM for decontamination of patient respiratory tract. Although complete decontamination of the respiratory tract was not achieved during the leukocytopenic period, BMT was successful, and there were no life-threatening infectious complications. Although inhaled VCM-induced allergic reaction may be a very rare complication in the BMT setting, careful clinical attention should be paid to such patients.

Citations

Nov 10, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Don HayesDavid J Feola
Dec 11, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Emmanuelle MercierLaurent Vecellio
Jul 30, 2009·Expert Opinion on Drug Delivery·Daniela Traini, Paul M Young
Nov 9, 2004·Archivos de bronconeumología·R Jordà MarcosUNKNOWN Grupo de Estudio de Infección Hospitalaria de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica

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