Inhaler usability of a pressurized metered dose inhaler and a soft mist inhaler in patients with COPD: A simulated-use study

Chronic Respiratory Disease
Bo DingUbaldo J Martin

Abstract

The objective of this study was to evaluate task performance and handling errors with soft mist inhalers (SMIs) or pressurized metered-dose inhalers (pMDIs) among patients with chronic obstructive pulmonary disease (COPD) experienced with, but not recently trained in, using these devices. This exploratory, noninterventional, simulated-use study (D5970R00004) assessed handling/usability of SMIs and pMDIs in inhaler-experienced patients with COPD (40-78 years; diagnosis ≥6 months). Patients received a device and instruction-for-use leaflet but no training and were recorded while performing tasks required for checking the device, priming, and dosing. Errors that could substantially affect the lung-delivered dose were considered critical. Sixteen of 61 patients (52% male) had used SMIs and 55 had used pMDIs. Thirty-one patients received an SMI and 30 a pMDI. Overall, 79% made ≥5 performance errors (SMI 94%; pMDI 63%) and 49% made ≥5 critical errors (SMI 68%; pMDI 30%). All patients made ≥1 error; three (all pMDI) made no critical errors. Regardless of the device used and previous inhaler experience, patient-centered training, education, and continuous retraining on correct inhaler use should be key aspects of routine patient care i...Continue Reading

References

Feb 23, 2010·Respiratory Medicine·R ZuwallackUNKNOWN Combivent Respimat Inhaler Study Group
Feb 12, 2011·The European Respiratory Journal·B L LaubeUNKNOWN International Society for Aerosols in Medicine
Mar 4, 2011·Respiratory Medicine·Andrea S MelaniUNKNOWN Gruppo Educazionale Associazione Italiana Pneumologi Ospedalieri
May 31, 2014·Respiratory Medicine·Pedro ChorãoJoão A Fonseca
May 31, 2014·Respiratory Medicine·Piyush AroraPitambar Chakraborty
Jul 18, 2015·International Journal of Chronic Obstructive Pulmonary Disease·Chaicharn PothiratWoranoot Choomuang
Aug 11, 2015·Annals of Internal Medicine·Wendy P BattistiYvonne E Yarker
Jan 27, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Janine A M WesterikDavid B Price
Feb 13, 2016·Multidisciplinary Respiratory Medicine·Roberto W Dal Negro, Massimiliano Povero
Sep 3, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Fulvio BraidoUNKNOWN Respiratory Effectiveness Group
Feb 10, 2017·The European Respiratory Journal·Mathieu MolimardPierre-Olivier Girodet
Mar 2, 2017·BMC Pulmonary Medicine·Kyra BartoloStephen Montefort

❮ Previous
Next ❯

Citations

Jan 28, 2020·Chronic Respiratory Disease·Maryam NavaieBartolome R Celli
Jul 24, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Timothy R Hudd
Nov 7, 2019·Therapeutic Advances in Respiratory Disease·Jose Luis Lopez-CamposJoan B Soriano
Oct 15, 2020·Drugs -- Real World Outcomes·Astrid Elander, Maria Gustafsson
Feb 23, 2021·Asian Journal of Pharmaceutical Sciences·Panoraia I SiafakaEvren Atlıhan Gündoğdu
Sep 29, 2019·Respiratory Medicine·Henry ChrystynNicolas Roche

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.