Inhaling xenon ameliorates l-dopa-induced dyskinesia in experimental parkinsonism

Movement Disorders : Official Journal of the Movement Disorder Society
Jérôme BaufretonErwan Bezard

Abstract

Parkinson's disease motor symptoms are treated with levodopa, but long-term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophysiology of dyskinesia. Because the noble gas xenon inhibits excitatory glutamatergic signaling, primarily through allosteric antagonism of the N-methyl-d-aspartate receptors, we aimed to test its putative antidyskinetic capabilities. We first studied the direct effect of xenon gas exposure on corticostriatal plasticity in a murine model of levodopa-induced dyskinesia We then studied the impact of xenon inhalation on behavioral dyskinetic manifestations in the gold-standard rat and primate models of PD and levodopa-induced dyskinesia. Last, we studied the effect of xenon inhalation on axial gait and posture deficits in a primate model of PD with levodopa-induced dyskinesia. This study shows that xenon gas exposure (1) normalized synaptic transmission and reversed maladaptive plasticity of corticostriatal glutamatergic projections associated with levodopa-induced dyskinesia, (2) ameliorated dyskinesia in rat and nonhuman primate models of PD and dyskinesia, and (3) improved gait ...Continue Reading

References

Jan 1, 1992·Clinical Neurology and Neurosurgery·B R Bloem
Apr 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·K Jellinger
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E C HirschF Javoy-Agid
Aug 3, 2001·Nature Reviews. Neuroscience·E BezardC E Gross
Apr 1, 2003·Nature Neuroscience·Barbara PicconiPaolo Calabresi
May 13, 2003·Nature Medicine·Erwan BézardPierre Sokoloff
Aug 10, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Bastiaan R BloemNir Giladi
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefan SchusterErwan Bezard
Jul 9, 2008·Current Opinion in Neurology·Tjitske A BoonstraBastiaan R Bloem
Aug 1, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Nir Giladi, Alice Nieuwboer
Apr 23, 2010·Science Translational Medicine·Mohamed R AhmedErwan Bezard
Oct 23, 2010·Neuroreport·Baptiste BessièreGuy Simonnet
Dec 1, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stefania FasanoRiccardo Brambilla
Jul 23, 2011·Lancet Neurology·John G NuttAlice Nieuwboer
Nov 2, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Susan H FoxCristina Sampaio
Dec 2, 2011·Parkinsonism & Related Disorders·Julie NantelHelen Bronte-Stewart
Jan 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amandine BerthetMarie-Laure Martin-Negrier
Sep 15, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Susan H FoxErwan Bezard
Oct 9, 2012·The Journal of Clinical Investigation·Gregory PorrasErwan Bezard
Jul 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David GrabliChantal François
May 29, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Erwan BezardSonia M Poli
Apr 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Nikhil M UrsMarc G Caron
May 29, 2015·Lancet Neurology·Jorik NonnekesBastiaan R Bloem
Jul 26, 2015·Progress in Neurobiology·Matthieu F BastideErwan Bézard
Aug 15, 2015·Anesthesia and Analgesia·Lawrence Siu-Chun LawTong Joo Gan
Jun 29, 2016·Nature Neuroscience·Paolo CalabresiBarbara Picconi
Sep 30, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Wesley ThevathasanUNKNOWN Movement Disorders Society PPN DBS Working Groupin collaboration with the World Society for Stereotactic and Functional Neur

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Citations

Dec 7, 2019·Journal of Neural Transmission·Déborah Le NoguePatrick Pierre Michel
Oct 28, 2019·British Journal of Pharmacology·Daniela MercatelliMichele Morari
Dec 5, 2019·Journal of Translational Medicine·A P DobrovolskyV A Dubynin
Jan 30, 2021·Frontiers in Pharmacology·Maurício Dos Santos PereiraElaine Del Bel
Oct 16, 2019·Journal of Chemical Information and Modeling·D A WinklerI Katz

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