Inheritable forms of medullary thyroid carcinoma

Biochimie
Anne BachelotMartin Schlumberger

Abstract

Medullary thyroid carcinoma (MTC) arises from parafollicular or C cells of the thyroid that produce calcitonin. It accounts for 5-10% of all thyroid cancers. Hereditary MTC represents 20-30% of all MTCs. It can be transmitted with an autosomal dominant pattern, either as a single entity, familial MTC, or it can arise as part of a multiple endocrine neoplasia (MEN) syndrome type 2A or 2B. The identification of hereditary MTC has been facilitated in recent years by the direct analysis of the ret proto-oncogene.

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Citations

Oct 31, 2003·Journal of the American College of Surgeons·Suzanne E ShapiroDouglas B Evans
Dec 14, 2004·Thyroid : Official Journal of the American Thyroid Association·Yun Jae ChungJae Hoon Chung
May 16, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chin-Feng ChangTien-Chun Chang
Jun 9, 2007·Expert Review of Anticancer Therapy·Gianlorenzo DionigiLuigi Bartalena
May 26, 2004·Clinics in Laboratory Medicine·Nicole Massoll, Ernest L Mazzaferri
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Adriana M Alvares Da SilvaJanete M Cerutti
Dec 3, 2016·Annals of Surgical Treatment and Research·Cho Rok LeeCheong Soo Park

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