PMID: 6967213May 1, 1980Paper

Inheritance of acquired immunological tolerance to foreign histocompatibility antigens in mice

Proceedings of the National Academy of Sciences of the United States of America
R M Gorczynski, E J Steele

Abstract

CBA mice were rendered tolerant of major histocompatibility antigens of A/J mice by neonatal injection of 100 x 10(6) lymphoid cells of (CBA X A/J)F1 followed by repeated injections of F1 cells at 2-week intervals throughout the study. When adult (8 weeks old), 10 tolerant or normal CBA males were mated to normal CBA females. Spleen cells of the progeny were tested for their ability to mount a cytotoxic T lymphocyte response in vitro against A/J antigens or against C57BL/6J and B10.A (2R) antigens in a cell-mediated lympholysis (CML) assay. A significant proportion (50-60%) of first-generation offspring of tolerant fathers failed to produce detectable anti-A/J cytotoxic responses but responded in the normal range to stimulation by C57BL/6J or B10.A (2R). Second-generation offspring derived from mating animals born of tolerant male parents--either brother x sister matings (incross or matings to normal CBA mice (outcross)--also showed a high proportion (20-40%) with diminished anti-A/J CML responses when similarly tested in vitro. Thus, a specific acquired somatic characteristic in the immune system (tolerance to major histocompatibility antigens) induced in male mice shows significant transmission to first- and second-generation...Continue Reading

References

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Citations

Jan 1, 1982·Acta Biotheoretica·H van Waesberghe
Jan 1, 1985·Immunogenetics·C A Cooper-WillisG A Leslie
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E Nisbet-Brown, T G Wegmann
Nov 17, 1984·British Medical Journal·K Ikwueke
Jun 7, 1985·Journal of Theoretical Biology·C C King
Apr 1, 1982·Immunology Today·J Urbain, C Wuilmart
Dec 1, 1982·Medical Hypotheses·R S Warlow
Oct 27, 2018·Science·Andrew H MoellerMichael W Nachman
Feb 9, 1989·Nature·J Cairns
May 25, 1989·Nature·H M Temin
Apr 9, 1981·Nature·A McLarenE Simpson
Jan 1, 1989·Molecular Reproduction and Development·E J Steele
Jul 24, 2003·Nature Reviews. Immunology·Juraj Ivanyi
Dec 4, 2019·Scandinavian Journal of Immunology·Edward J Steele, Robyn A Lindley
Oct 15, 1981·International Journal of Cancer. Journal International Du Cancer·L TomatisV Ponomarkov
Aug 26, 2019·Progress in Biophysics and Molecular Biology·Edward J SteeleN Chandra Wickramasinghe
Mar 21, 2021·Developmental Biology·Nelson R Cabej
Jul 17, 1981·Science·R Lewin

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