Inheritance of serum autoantibody, reduced serum IgA and autoimmune disease in a canine breeding colony

Veterinary Immunology and Immunopathology
M J Day

Abstract

Immunological parameters were examined in 113 English cocker spaniel dogs from two breeding kennels. Dogs from kennel 1 (n = 86) were grouped as having idiopathic cardiomyopathy (n = 19), autoimmune or other disease (n = 7) or being clinically normal (n = 60). Dogs from kennel 2 (n = 27) were all clinically normal and used for comparative purposes. There was a high incidence of serum antinuclear antibody (ANA) amongst all groups from kennel 1 (39/82 dogs tested), with anti-thyroglobulin and anti-erythrocyte antibodies also recorded in a dog with systemic lupus erythematosus. Thirty percent of dogs with idiopathic cardiomyopathy had anti-mitochondrial antibody. Thirteen dogs from kennel 1 had reduced serum IgA (< or = 0.3 mg/ml), but there was no consistent abnormality in the concentration of serum IgG, IgM, complement C3 or C4 in these thirteen dogs, or other dogs from this kennel. No immunological abnormality was recorded in dogs from kennel 2. Pedigree analysis of dogs from kennel 1 revealed inheritance of autoimmune disease, serum ANA and low serum IgA within several breeding lines. Inheritance of idiopathic cardiomyopathy was recorded through three generations and a strong association demonstrated between the presence of th...Continue Reading

References

Jun 17, 1978·The Veterinary Record·R A Harcourt
Jul 1, 1992·Research in Veterinary Science·M J Day, W J Penhale
Mar 1, 1987·Journal of Comparative Pathology·A Spencer, P Greaves
Jun 1, 1985·Journal of Molecular and Cellular Cardiology·H P Schultheiss, H D Bolte
Jan 1, 1987·Veterinary Research Communications·M J Day, W J Penhale
Jul 1, 1988·Journal of Pediatric Gastroenterology and Nutrition·C Cunningham-Rundles
Nov 1, 1986·Veterinary Immunology and Immunopathology·S D MoroffK E Noone
Apr 1, 1985·Australian Veterinary Journal·W F RobinsonJ P Gooding
Aug 1, 1971·The Journal of Experimental Medicine·R M Lewis, R S Schwartz
Jan 1, 1983·Immunological Reviews·R L DawkinsP J Zilko
Jul 1, 1995·Veterinary Pathology·P W SnyderP J Felsburg
Nov 1, 1995·Immunology Today·A Fischer, A Arnaiz-Villena
Nov 1, 1993·Journal of Comparative Pathology·M J DayL M Powell

❮ Previous
Next ❯

Citations

Jul 14, 1998·Veterinary Immunology and Immunopathology·A J GermanM J Day
Oct 3, 1999·Veterinary Immunology and Immunopathology·M J Day
Oct 3, 1999·Veterinary Immunology and Immunopathology·N C Pedersen
Feb 9, 2000·The Journal of Small Animal Practice·M J Day
Jan 23, 2004·Journal of the American Veterinary Medical Association·Sybille A MillerAnne S Hale
Dec 23, 2014·Developmental and Comparative Immunology·Marcel FrankowiackLennart Hammarström
Aug 25, 2004·The Veterinary Clinics of North America. Small Animal Practice·Michael R O'Grady, M Lynne O'Sullivan
Oct 3, 2006·Psychosomatic Medicine·Glenn V OstirKenneth J Ottenbacher
Jan 13, 2009·Journal of Occupational and Environmental Medicine·Marie S O'Neill, Kristie L Ebi
Oct 8, 2003·Journal of Veterinary Internal Medicine·M Alexis SeguinJay F Levine
Aug 15, 2021·Veterinary Medicine and Science·Niels GrütznerJörg M Steiner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Research in Veterinary Science
M J Day, W J Penhale
Veterinary Immunology and Immunopathology
L ChabanneJ C Monier
Australian and New Zealand Journal of Medicine
D G Legge, P A Hutton
The Tohoku Journal of Experimental Medicine
C Itoh
© 2021 Meta ULC. All rights reserved