Inheritance patterns and stability of DNA methylation variation in maize near-isogenic lines

Genetics
Qing LiNathan M Springer

Abstract

DNA methylation is a chromatin modification that contributes to epigenetic regulation of gene expression. The inheritance patterns and trans-generational stability of 962 differentially methylated regions (DMRs) were assessed in a panel of 71 near-isogenic lines (NILs) derived from maize (Zea mays) inbred lines B73 and Mo17. The majority of DMRs exhibit inheritance patterns that would be expected for local (cis) inheritance of DNA methylation variation such that DNA methylation level was coupled to local genotype. There are few examples of DNA methylation that exhibit trans-acting control or paramutation-like patterns. The cis-inherited DMRs provide an opportunity to study the stability of inheritance for DNA methylation variation. There was very little evidence for alterations of DNA methylation levels at these DMRs during the generations of the NIL population development. DNA methylation level was associated with local genotypes in nearly all of the >30,000 potential cases of inheritance. The majority of the DMRs were not associated with small RNAs. Together, our results suggest that a significant portion of DNA methylation variation in maize exhibits locally (cis) inherited patterns, is highly stable, and does not require ac...Continue Reading

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Citations

Sep 1, 2015·Seminars in Cell & Developmental Biology·Iris HövelMaike Stam
Sep 2, 2015·Seminars in Cell & Developmental Biology·Nathan M Springer, Karen M McGinnis
Jul 8, 2015·BMC Genomics·Jack M ColicchioLena C Hileman
May 10, 2016·Nature Reviews. Genetics·Aaron TaudtFrank Johannes
Jan 20, 2017·Journal of Evolutionary Biology·J Colicchio
Jul 4, 2017·Nature Reviews. Genetics·Nathan M Springer, Robert J Schmitz
Oct 14, 2017·Ecology Letters·Christina L RichardsKoen J F Verhoeven
Nov 1, 2014·Expert Review of Endocrinology & Metabolism·Amber MajnikRobert H Lane
Jan 23, 2020·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Jia YuLi Pu
Oct 13, 2016·Annual Review of Genetics·Leandro Quadrana, Vincent Colot
Jun 30, 2018·BMC Genomics·Elizabeth S A Sollars, Richard J A Buggs
Jan 9, 2021·Current Opinion in Plant Biology·Ning Yang, Jianbing Yan
Jan 15, 2021·Current Opinion in Plant Biology·Jaclyn M Noshay, Nathan M Springer
Aug 5, 2021·Current Opinion in Biotechnology·Peter A CrispLee T Hickey
Aug 13, 2021·Evolution & Development·Jeannie MoungerChristina L Richards
Aug 28, 2021·International Journal of Molecular Sciences·Thanvi Srikant, Anjar Tri Wibowo

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