PMID: 7014422Jan 1, 1981Paper

Inheritance patterns of idiotype expression: maternal-fetal immune regulatory networks

Immunogenetics
J C Olson, G A Leslie

Abstract

The production of Id-1, a cross-reactive idiotype associated with rat anti-group. A streptococcal carbohydrate antibodies, by 11 strains of rats indicates that genes coding for Id-1 are in the germline. Its expression, however, follows a complex inheritance pattern. It was our intent in these studies to determine if immune responsiveness of streptococcus (GASV) immunized females could alter Id-1 expression of GASV-immunized progeny, and, in turn, introduce complications in Id-1 inheritance patterns. - We observed that Id-1-specific immune reactivity of GASV-immunized females could induce significant alterations in Id-1 production by progeny. The relationship between maternal and progeny Id-1 was complex, reflecting the complexity of autologous regulation of Id-1 production, and could be the opposite of what one would predict based upon parental transfer of Id-1 regulatory genes. The nongenetic nature of the maternal regulatory influence was confirmed by foster-mother studies. - We conclude that antigen-induced maternal immune responsiveness can exert a permanent regulatory influence on idiotype expression by progeny and consequently introduce error in to the interpretations of idiotype inheritance patterns. The recognition of t...Continue Reading

References

May 15, 1976·Lancet·D I EvansM Palmer
Sep 1, 1977·European Journal of Immunology·I J WeilerH Cosenza
Aug 14, 1971·Lancet·E J Field, E A Caspary
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Dec 1, 1969·The Journal of Experimental Medicine·G A Leslie, L W Clem
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R M Gorczynski, E J Steele
Oct 7, 1958·Annals of the New York Academy of Sciences·L A PEER
Mar 15, 1955·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R HALLIDAY

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Citations

Jan 1, 1984·Immunogenetics·A R Brown, P D Gottlieb
Jan 1, 1985·Immunogenetics·C A Cooper-WillisG A Leslie
Jan 1, 1985·Developmental and Comparative Immunology·J C Olson, G A Leslie
Sep 1, 1993·Developmental and Comparative Immunology·K MehrazarY B Kim
Jan 1, 1990·International Reviews of Immunology·J E Berman, F W Alt
Jan 1, 1983·Annals of the New York Academy of Sciences·L S RodkeyF L Adler
Jun 1, 1989·The Journal of Pediatrics·W BorkowskyS Chandwani
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S Marques-de-Araújo, M A Cardoso

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