Inherited platelet functional disorders: General principles and practical aspects of management

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Adrienne Lee, Man-Chiu Poon

Abstract

Platelets are a critical component for effecting hemostasis and wound healing. Disorders affecting any platelet pathway mediating adhesion, activation, aggregation and procoagulant surface exposure can result in a bleeding diathesis. Specific diagnosis even with advanced techniques which are unavailable to most centers is often difficult. Inherited platelet function disorders therefore represent a heterogeneous and complex collection of disorders with a spectrum of bleeding severity, from relatively mild (and easily missed or misdiagnosed) to severe bleeding phenotype with salient diagnostic features. We advocate the use of bleeding assessment tools to help identification of patients and more importantly for assessment of individual patient bleeding phenotype to guide management decisions for treating and preventing bleeding. The complex management of these patients is best coordinated in a multidisciplinary comprehensive care clinic setting expert in managing bleeding disorders and associated complications, with particular attention to the physical and psychosocial health of patients and their families. Depending on the bleeding phenotype, the location and severity of bleeding, and the nature of an invasive procedure, availabl...Continue Reading

Citations

Nov 22, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Man-Chiu Poon, Robert T Card
Jul 23, 2020·Case Reports in Medicine·Thejus T JayakrishnanPrerna Mewawalla
May 1, 2021·International Journal of Molecular Sciences·José María BastidaMaría Luisa Lozano
May 1, 2021·International Journal of Molecular Sciences·Verónica Palma-BarquerosJosé Rivera
Mar 4, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Nouf Al-NumairTarek Owaidah
Dec 9, 2021·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Victor Tieghi NetoPaulo Sergio da Silva Santos
Jan 7, 2022·Seminars in Thrombosis and Hemostasis·Akbar DorgalalehAbbas Ahmadi
Jan 13, 2022·Seminars in Thrombosis and Hemostasis·Amir SamiiAkbar Dorgalaleh

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