Inherited variation at MC1R and histological characteristics of primary melanoma.

PloS One
Nicholas J TaylorP A Kanetsky

Abstract

Variation in the melanocortin-1receptor (MC1R) gene is associated with pigmentary phenotypes and risk of malignant melanoma. Few studies have reported on MC1R variation with respect to tumor characteristics, especially clinically important prognostic features. We examined associations between MC1R variants and histopathological melanoma characteristics. Study participants were enrolled from nine geographic regions in Australia, Canada, Italy and the United States and were genotyped for MC1R variants classified as high-risk [R] (D84E, R142H, R151C, R160W, and D294H, all nonsense and insertion/deletion) or low-risk [r] (all other nonsynonymous) variants. Tissue was available for 2,160 white participants of the Genes, Environment and Melanoma (GEM) Study with a first incident primary melanoma diagnosis, and underwent centralized pathologic review. No statistically significant associations were observed between MC1R variants and AJCC established prognostic tumor characteristics: Breslow thickness, presence of mitoses or presence of ulceration. However, MC1R was significantly associated with anatomic site of melanoma (p = 0.002) and a positive association was observed between carriage of more than one [R] variant and melanomas arisi...Continue Reading

References

Dec 20, 1989·Journal of the National Cancer Institute·W H ClarkA C Halpern
Aug 12, 1998·The Journal of Investigative Dermatology·F Ichii-JonesR C Strange
Jul 15, 1999·Biochemical and Biophysical Research Communications·H B SchiöthJ L Rees
Oct 13, 2000·Human Molecular Genetics·N FlanaganJ L Rees
Feb 8, 2002·American Journal of Human Genetics·Peter A KanetskyTimothy R Rebbeck
May 20, 2003·Pigment Cell Research·Richard A SturmNicholas G Martin
Oct 1, 1959·Archives of Ophthalmology·D PATON, L B THOMAS
Dec 4, 2004·Cancer Causes & Control : CCC·Colin B BeggUNKNOWN GEM Study Group
Mar 25, 2006·International Journal of Epidemiology·Colin B BeggUNKNOWN GEM Study Group
Apr 8, 2006·The Journal of Investigative Dermatology·Alexander J StratigosAndreas D Katsambas
Sep 20, 2006·Cancer Research·Peter A KanetskyMarianne Berwick
Sep 22, 2006·International Journal of Cancer. Journal International Du Cancer·Tadeusz DebniakJan Lubinski
Jan 16, 2007·The Journal of Investigative Dermatology·Irene OrlowUNKNOWN GEM Study Group
Mar 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Phyllis A GimottyDuPont Guerry
Mar 28, 2008·International Journal of Cancer. Journal International Du Cancer·Sara RaimondiMaria Concetta Fargnoli
Dec 17, 2008·Pigment Cell & Melanoma Research·Veronica HöiomJohan Hansson
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Mar 20, 2010·Cancer·Peter A KanetskyTimothy R Rebbeck
Dec 4, 2010·International Journal of Cancer. Journal International Du Cancer·Patricia F WilliamsDavid C Whiteman
Nov 19, 2011·International Journal of Cancer. Journal International Du Cancer·Anne E CustMark A Jenkins
Dec 6, 2011·American Journal of Surgery·Glenda G CallenderKelly M McMasters
Oct 16, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy E ThomasMarianne Berwick
Jun 12, 2014·International Journal of Cancer. Journal International Du Cancer·Elena PasqualiUNKNOWN M-SKIP Study Group

❮ Previous
Next ❯

Citations

Feb 2, 2017·Melanoma Research·Cristina PellegriniMaria Concetta Fargnoli
Dec 9, 2016·Pigment Cell & Melanoma Research·Eduardo NagoreRajiv Kumar
May 21, 2020·International Journal of Molecular Sciences·Kevin YangAndrzej T Slominski
Dec 27, 2018·The Australasian Journal of Dermatology·David John Mackay Smith
Apr 7, 2020·Journal of Cutaneous Pathology·Atrin ToussiMaija Kiuru
Apr 23, 2016·International Journal of Cancer. Journal International Du Cancer·Nicholas J TaylorUNKNOWN GEM Study Group
Jan 8, 2021·Human Molecular Genetics·Ernest MangantigMatthew H Law

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
P A KanetskyTimothy R Rebbeck
© 2021 Meta ULC. All rights reserved