PMID: 376371Jan 1, 1979Paper

Inhibin--fact or artifact

Molecular and Cellular Endocrinology
F H de Jong

Abstract

Peripheral concentrations of follicle-stimulating hormone (FSH) in male as well as in female animals appear to be partly regulated by inhibin, a protein which is secreted by the gonads. The molecular structure of this substance is still unknown, and the mechanism(s) of its action on the pituitary or hypothalamic level is not clear. Much of the confusion about inhibin stems from the fact that no generally accepted definition of inhibin exists and that fundamentally different biological assay systems have been used by different groups. Therefore this short review starts with a discussion of the definition of inhibin and the assay principles. From the available information on the site of origin of the hormone it appears likely that inhibin is produced in the Sertoli cells of the testis and the granulosa cells of the ovary. The available data on the chemical nature of inhibin suggest that different principles, acting on different sites of the hypothalamic--pituitary axis, might be present in preparations with inhibin-like activity. Finally, with respect to the biological significance of inhibin, it seems that inhibin could play a more important role in the feedback regulation of FSH in the adult female than in the adult male animal.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·N B Schwartz, C P Channing
Aug 1, 1978·Endocrinology·M ChowdhuryE Steinberger
Jan 1, 1979·The Journal of Endocrinology·F H de JongH J van der Molen
Jan 1, 1976·Hormone Research·S ChariP Franchimont
Sep 1, 1976·Endocrinology·A Steinberger, E Steinberger
Sep 2, 1976·Nature·F H De Jong, R M Sharpe
Nov 1, 1975·The American Journal of Anatomy·D C Herbert
Apr 1, 1976·Endocrinology·E J KeoghD M De Kretser
Jun 1, 1976·Endocrinology·S G NandiniN R Moudgal
Mar 1, 1974·General and Comparative Endocrinology·H Heller
Sep 1, 1974·The Journal of Endocrinology·B P Setchell, F Jacks
Feb 15, 1969·Experientia·G LugaroG L Gianfranceschi
Jul 1, 1932·Science·D R McCullagh

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Citations

Jan 1, 1987·Journal of Steroid Biochemistry·D T Baird
Aug 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J G LoeberF X van Leeuwen
Feb 1, 1981·Molecular and Cellular Endocrinology·E H JansenH J van der Molen
Nov 1, 1982·Molecular and Cellular Endocrinology·F Le Gac, D M de Kretser
Aug 1, 1983·Molecular and Cellular Endocrinology·M DobosF J Morgan
Oct 1, 1985·Molecular and Cellular Endocrinology·S van DijkH J van der Molen
Sep 1, 1985·Molecular and Cellular Endocrinology·F H de Jong, D M Robertson
Jan 1, 1986·Molecular and Cellular Endocrinology·M FukudaH Matsuo
Dec 1, 1987·Molecular and Cellular Endocrinology·T SuzukiM Igarashi
Dec 1, 1987·Molecular and Cellular Endocrinology·I MerchenthalerA Negro-Vilar
Mar 1, 1988·Molecular and Cellular Endocrinology·Z ZhangH G Burger
Nov 1, 1988·Baillière's Clinical Endocrinology and Metabolism·R N Clayton
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D YamashiroM R Sairam
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N LingR Guillemin
Jan 1, 1985·Journal of Immunoassay·R G HammondsM Westphal
Jul 3, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Stephen J Winters, Joseph P Moore
Jul 1, 1983·Journal of Steroid Biochemistry·J P MatherC W Bardin
Jan 1, 1987·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·C RivierW Vale
Jan 1, 1987·Drug and Chemical Toxicology·J Fernandez-VanCleveP M Zavos
Dec 1, 1988·The Anatomical Record·S V GardeA R Sheth
Jun 1, 1986·International Journal of Andrology·U NatrajA R Sheth
Nov 27, 1985·Biochemical and Biophysical Research Communications·J RivierW Vale
May 22, 1980·Nature·R S Scott, H G Burger
Jan 1, 1982·Annals of the New York Academy of Sciences·H W BakerH D Niall
Dec 1, 1983·Clinical Endocrinology·M J FarthingA M Dawson
Jan 1, 1987·Critical Reviews in Toxicology·F X van Leeuwen, B Sangster
Jan 1, 1985·The Prostate·G R VanageA R Sheth
Sep 1, 1980·Archives of Andrology·E S Hafez
Jan 1, 1990·Archives of Andrology·D Dinulovic, G Radonjic
Mar 1, 1983·Journal of Andrology·L Seethalakshmi, A Steinberger
Aug 30, 1985·Biochemical and Biophysical Research Communications·H van HalbeekK Schmid

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