Jun 2, 2020

Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia

Endocrinology, Diabetes & Metabolism Case Reports
Rachel WurthFady Hannah-Shmouni

Abstract

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing syndrome (CS). This condition is characterized by glucocorticoid and/or mineralocorticoid excess, and is commonly regulated by aberrant G-protein coupled receptor expression may be subclinical, allowing the disease to progress for years undetected. Inhibin A is a glycoprotein hormone and tumor marker produced by certain endocrine glands including the adrenal cortex, which has not been previously investigated as a potential tumor marker for PBMAH. In the present report, serum inhibin A levels were evaluated in three patients with PBMAH before and after adrenalectomy. In all cases, serum inhibin A was elevated preoperatively and subsequently fell within the normal range after adrenalectomy. Additionally, adrenal tissues stained positive for inhibin A. We conclude that serum inhibin A levels may be a potential tumor marker for PBMAH. PBMAH is a rare cause of CS. PBMAH may have an insidious presentation, allowing the disease to progress for years prior to diagnosis. Inhibin A is a heterodimeric glycoprotein hormone expressed in the gonads and adrenal cortex. Inhibin A serum concentrations are elevated in some patients with PBMAH, ...Continue Reading

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Mentioned in this Paper

Recombinant Inhibins
Heterotrimeric G-protein Binding
Endocrine Glands
Adrenal Gland Tissue
Serum
Operative Surgical Procedures
Disease Progression
Receptor
Cushing Syndrome
Bilateral

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