PMID: 11312150Apr 20, 2001Paper

Inhibin A is a follicle stimulating hormone-responsive marker of granulosa cell differentiation, which has both autocrine and paracrine actions in sheep

The Journal of Endocrinology
B K Campbell, D T Baird

Abstract

The aim of these studies was to examine the origin, control and local actions of inhibin A in monovular species, using the sheep as a model. Experiment 1 examined the pattern of mRNA expression for the inhibin subunits in relation to follicular size and pattern of expression to other differentiative markers in granulosa (P450 aromatase) and thecal cells (P450 17alpha-hydroxylase). Experiment 2 examined the pattern of inhibin A production, in relation to oestradiol, by granulosa cells induced to differentiate in vitro with follicle-stimulating hormone (FSH). Experiment 3 examined possible paracrine and autocrine actions of inhibin A by determining the effect of addition of human recombinant inhibin A and/or antiserum to inhibin on gonadotrophin-stimulated cellular differentiation. The results of Experiment 1 showed that expression of mRNA encoding inhibin subnuits alpha, beta(A) and beta(B) is greater (P<0.05) in large oestrogenic follicles than in small follicles but that only expression of the inhibin beta(A) subunit differs (P<0.05) between large oestrogenic and non-oestrogenic follicles. Expression of 17alpha-hydroxylase, but not of the luteinising hormone (LH) receptor, in thecal cells was related to both the size and the o...Continue Reading

Citations

Jun 24, 2003·Animal Reproduction Science·Philip G Knight, Claire Glister
Jun 24, 2003·Animal Reproduction Science·O J GintherD R Bergfelt
Mar 24, 2011·Reproduction, Fertility, and Development·R J ScaramuzziR Webb
Dec 17, 2008·Biology of Reproduction·Raji KanakkaparambilKevin D Sinclair
Jul 3, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Rachel C HirstHarry M Charlton
Jun 12, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Fiammetta BerlinguerGiovanni G Leoni
Aug 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Phil G Knight, Claire Glister
Jun 15, 2011·Molecular and Cellular Endocrinology·Phil G KnightClaire Glister
Jan 22, 2015·Reproductive Biology and Endocrinology : RB&E·Rex John ScaramuzziJoëlle Dupont
May 29, 2012·Biochimica Et Biophysica Acta·Flor Sánchez, Johan Smitz
Oct 30, 2016·Theriogenology·Khairy M A ZoheirAbdel Halim Harrath
Oct 30, 2012·Clinical and Experimental Reproductive Medicine·Yong-Pil Cheon
Sep 27, 2019·Scientific Reports·Fatema B AlmughlliqMurray D Mitchell
Jul 23, 2014·Endocrine Reviews·Yogeshwar MakanjiTeresa K Woodruff
Jun 23, 2016·Cold Spring Harbor Perspectives in Biology·Maria Namwanje, Chester W Brown
Jul 28, 2018·Journal of Assisted Reproduction and Genetics·Apostolos KaponisGeorge Decavalas
Oct 13, 2020·Metabolism: Clinical and Experimental·Eirini BouzoniChristos S Mantzoros

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