PMID: 2123496Nov 1, 1990Paper

Inhibin, gonadotrophins and sex steroids in dogs with Sertoli cell tumours

The Journal of Endocrinology
A J GrootenhuisF H de Jong

Abstract

Inhibin bioactivity and mRNA for inhibin subunits were measured in four dog Sertoli cell tumours and in the testes of five normal control dogs. The tumours contained increased levels of inhibin (P less than 0.05) and mRNA for the alpha and beta B subunits when compared with controls, whereas the mRNA for the beta A subunit was not detected in tumours or control testes. The inhibin bioactivity was associated with a 32 kDa molecule in both Sertoli cell tumours and normal dog testes; no higher molecular weight forms were found after sodium dodecyl sulphate-polyacrylamide gel electrophoresis. Peripheral levels of immunoassayable inhibin in dogs with Sertoli cell tumours were higher than those in the controls (P = 0.01), indicating that it might be possible to use this parameter as a marker for Sertoli cell tumours. Other testicular tumours, however, might also secrete immunoactive inhibin. The increased inhibin concentrations are likely to be the cause of the suppressed peripheral levels of FSH (P less than 0.02). However, peripheral levels of LH (P less than 0.02) and testosterone (P less than 0.01) were also suppressed in the dogs with Sertoli cell tumours, whereas the concentrations of oestradiol in the peripheral plasma of both...Continue Reading

Citations

Aug 1, 1995·The Prostate·K KharbandaS Duraiswami
Jun 11, 2008·Histochemistry and Cell Biology·Christina RüttingerRalph Brehm
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·F H De JongJ G Klijn
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J ToppariT T Salmi
Nov 27, 2009·The Journal of Veterinary Medical Science·Ryohei IchimuraKunitoshi Mitsumori
Jan 15, 2013·Journal of Veterinary Internal Medicine·C BrömelA J Conley
Aug 1, 1994·Clinical Endocrinology·H G Burger
Nov 30, 2006·The Veterinary Clinics of North America. Equine Practice·Patrick M McCueBill L Lasley
Mar 4, 2009·Journal of Veterinary Science·Chi-Ho YuJung-Hyang Sur
Dec 12, 2001·Endocrine Reviews·G P RisbridgerD M Robertson

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