Inhibin secretion in the stallion

Equine Veterinary Journal
S NagataK Taya

Abstract

To examine the physiological role of inhibin in the stallion, a heterologous radioimmunoassay (RIA) based on a bovine RIA was validated and used to measure immunoreactive (ir)-inhibin concentrations in plasma and testicular homogenates. The bioactivity of equine testicular inhibin was also examined using an assay for suppression of FSH secretion from rat anterior pituitary cells. In addition, to identify the cell responsible for secreting testicular inhibin, the localisation of inhibin in the testis was investigated by an immunohistochemical method using a polyclonal antibody against (Tyr30)-porcine inhibin alpha(1-30) NH2. In the RIA, parallel dose response curves were obtained for the bovine inhibin standard and serial dilutions of stallion plasma and equine testicular homogenates. Parallel FSH inhibition curves were also observed for the bovine inhibin standard and serial dilutions of equine testicular homogenates in the bioassay. The inhibition of FSH secretion from rat pituitary cells by equine testicular homogenates was neutralised by an antiserum against bovine inhibin in vitro. Plasma concentrations of ir-inhibin, testosterone and oestradiol-17beta in stallions decreased abruptly after bilateral gonadectomy and FSH and ...Continue Reading

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Citations

Dec 21, 2002·Biology of Reproduction·Yumiko TanakaKazuyoshi Taya
Feb 28, 2003·Biology of Reproduction·Thomas KlonischSabine Hombach-Klonisch
Jun 30, 2006·The Journal of Reproduction and Development·Qiang WengKazuyoshi Taya
Nov 3, 2010·The Journal of Veterinary Medical Science·Saroch KaewmaneeKazuyoshi Taya
Dec 29, 2004·Domestic Animal Endocrinology·David J Phillips
Oct 9, 1998·The Journal of Veterinary Medical Science·S FujimuraJ Yamada
Feb 19, 2002·Oncogene·M Teresa ValenzuelaF Javier Oliver
Feb 19, 2002·Oncogene·Mana MiyakodaMasami Watanabe
Mar 16, 2002·Oncogene·Qing-Bai SheZigang Dong
Apr 21, 2001·Oncogene·W R Taylor, G R Stark
Feb 19, 2002·Oncogene·Tej K Pandita
Mar 19, 2019·Journal of Cellular and Molecular Medicine·Chunxiao YuQingbo Guan
Sep 6, 2005·The Journal of Reproduction and Development·Qiang WengKazuyoshi Taya
May 29, 2002·Oncogene·Utz KrugH Phillip Koeffler
Jun 8, 2012·The Journal of Reproduction and Development·Pramod DhakalKazuyoshi Taya
Oct 6, 2004·Equine Veterinary Journal·B BilińskaM Tischner

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