Inhibited activities in CCAAT/enhancer-binding protein, activating protein-1 and cyclins after hepatectomy in rats with thioacetamide-induced liver cirrhosis

Biochemical and Biophysical Research Communications
Gang ZhaoMasao Tanaka

Abstract

Transcriptional activation of nuclear factor (NF)-kappaB, signal transducers and activators of transcription (STAT) 3, activating protein (AP)-1 and CCAAT/enhancer-binding protein (C/EBP) plays an important role in liver regeneration by modulating cell cycle regulators. The regeneration of cirrhotic liver after hepatectomy is inhibited despite intact expression of growth factors. To elucidate the mechanism involved, regeneration responses in growth factor receptors, transcription factors, and cell cycle regulators after two-thirds hepatectomy were compared between rats with thioacetamide-induced cirrhotic and normal liver. The expression of c-met and epidermal growth factor receptor analyzed by RT-PCR and immunohistochemistry did not differ between the two groups. The activities of C/EBP and AP-1 evaluated by electrophoretic mobility shift assay were significantly inhibited in the cirrhotic group compared with those in the control group, but not those of NF-kappaB and STAT3. The expression of cyclin-D1, -E, and -A assessed by Western blot analysis was significantly decreased in the cirrhotic group compared with the control group. The level in p21(Cip1) or p27(Kip1) did not differ between the two groups. The liver regeneration e...Continue Reading

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Citations

Jul 29, 2005·Journal of Gastroenterology and Hepatology·Akira KatoYukio Yoshida
Sep 6, 2007·Drug Metabolism Reviews·K Cameron Falkner, Russell A Prough
Apr 22, 2015·Gastroenterology Research and Practice·Nikolaos P KaridisStamatios Theocharis
Sep 14, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nikolaos AndreatosTimothy M Pawlik
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Thomas S Helling
May 1, 2008·Experimental Biology and Medicine·Juan A Suárez-CuencaRolando Hernández-Muñoz
Dec 27, 2008·Journal of Hepato-biliary-pancreatic Surgery·Giuseppe Garcea, G J Maddern
Jun 13, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kelly LafaroTimothy M Pawlik
Nov 5, 2020·PLoS Genetics·Matthew R DewhurstPhilipp Kaldis

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