Inhibited hypothalamic-pituitary-thyroid axis in type I pseudohypoparathyroidism.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
U M Kabadi, R P Cech

Abstract

To assess the hypothalamic-pituitary-thyroid axis in two patients with the diagnosis of type I pseudohypoparathyroidism established previously by characteristic clinical features and laboratory findings, including low serum Ca++, high parathyroid hormone concentration, and subnormal urinary cyclic adenosine monophosphate (cAMP) responses to exogenous administration of parathyroid hormone. We determined serum thyroxine, triiodothyronine (T(3)), T(3) resin uptake, and 24-hour thyroidal uptake of 123 I before and after subcutaneous administration of thyroid-stimulating hormone (TSH), 10 U daily for 3 days. Serum TSH levels were determined before and again at 15, 30, 45, and 60 minutes after intravenous administration of thyrotropin-releasing hormone (TRH) (400 microg) after an overnight fast. Values noted in the two patients with type I pseudohypoparathyroidism were compared with those obtained in 10 normal volunteer control subjects. Serum thyroxine (T(4)), triiodothyronine (T(3)), T(3) resin uptake, and 24-hour 123 I uptake values for both patients with type I pseudohypoparathyroidism were within the normal ranges (5.5 to 11.5 microg/dL for T(4), 90 to 190 ng/dL for T(3), 35 to 45% for T(3) resin uptake, and 10 to 35% for 24-hou...Continue Reading

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Citations

Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M A Levine
Jun 23, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Jean-Louis WémeauVirginie Vlaeminck-Guillem

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