Inhibited intercellular communication as a mechanistic link between teratogenesis and carcinogenesis

Critical Reviews in Toxicology
R Loch-Caruso, J E Trosko

Abstract

Teratogenesis and carcinogenesis share many characteristics, leading to the speculation that they may also share pathogenic mechanisms. Direct intercellular communication mediated by membrane junctions is known to occur between a variety of cells and may play an important role in the control of cell growth and differentiation. Inhibition of junctional communication may be a mechanism common to both teratogenesis and carcinogenesis whereby cells and tissues are diverted from their normal differentiation paths. The multistage model of carcinogenesis predicts that the irreversibly initiated cell is at least partially regulated by the surrounding cells of a tissue, and that the initiated cell remains inactive until stimulated to proliferate by a tumor promotor. Tumor promoters may release the initiated cell from control of the surrounding tissue by interrupting intercellular communication, since many tumor promoters have now been shown to interfere with junctional communication in cultured mammalian cells. Furthermore, many tumorigenic cells have compromised junctional communication abilities. Similarly, it has been reasoned that the cells of an embryo must be able to communicate with each other to define tissue specificity and pat...Continue Reading

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Related Concepts

Tumor Promoters
Cell Communication
Cell Survival
Electronic
Embryonic Structures, Mammalian
Embryonic Structures, Nonmammalian
Intercellular Junctions
Malignant Neoplasms
Teratogens

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