PMID: 2118820Jun 11, 1990Paper

Inhibiting carbonic anhydrase in brain tissue increases the respiratory response to rebreathing CO2

Brain Research
J M Adams, N L Johnson

Abstract

To determine the respiratory effects of inhibiting carbonic anhydrase in brain tissue, we infused acetazolamide (ACZ) into the cisterna magna in anesthetized rats. Three concentrations, 4.5, 45 and 450 microM in artificial cerebrospinal fluid, were infused continuously at 2 microliter/min for 20 min and the responses to CO2 rebreathing trials were compared to sham CSF infusions without ACZ. Baseline, steady-state respiration during room air breathing was not affected by these doses of ACZ, but the two higher doses increased the minute ventilation rebreathing response. We conclude that inhibition of carbonic anhydrase in brain tissue increases the respiratory response to rebreathing CO2.

References

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Citations

Sep 1, 1995·Pflügers Archiv : European journal of physiology·S KönigH Seller
Sep 5, 2002·Respiratory Physiology & Neurobiology·Aleksandar NecakovJ Duffin
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·L J Teppema, Albert Dahan
Aug 21, 2001·Journal of Child Neurology·H PhilippiB Reitter
Apr 13, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alasdair I HoustonMark D Steer
Dec 7, 2018·Ecotoxicology and Environmental Safety·Yanhua LiuRuixin Guo

Related Concepts

Acetazolamide Sodium, (Sterile)
Brain
Carbon Dioxide
Carbonic Anhydrase Inhibitors
Dose-Response Relationship, Drug
August Rats
Respiration

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