Inhibiting cortisol response accelerates recovery from a photic phase shift

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Jennifer A MohawkTheresa M Lee

Abstract

Jetlag results when a temporary loss of circadian entrainment alters phase relationships among internal rhythms and between an organism and the outside world. After a large shift in the light-dark (LD) cycle, rapid recovery of entrainment minimizes the negative effects of internal circadian disorganization. There is evidence in the existing literature for an activation of the hypothalamic-pituitary-adrenal (HPA) axis after a photic phase shift, and it is possible that the degree of HPA-axis response is a determining factor of reentrainment time. This study utilized a diurnal rodent, Octodon degus, to test the prediction that the alteration of cortisol levels would affect the reentrainment rate of circadian locomotor rhythms. In experiment 1, we examined the effects of decreased cortisol (using metyrapone, an 11beta-hydroxylase inhibitor) on the rate of running-wheel rhythm recovery after a 6-h photic phase advance. Metyrapone treatment significantly shortened the length of time it took animals to entrain to the new LD cycle (11.5% acceleration). In experiment 2, we examined the effects of increased cortisol on the rate of reentrainment after a 6-h photic phase advance. Increasing plasma cortisol levels increased the number of d...Continue Reading

References

Mar 1, 1991·Physiology & Behavior·G J KantC P D'Angelo
Jun 1, 1985·Journal of Endocrinological Investigation·R De CosterL Wouters
Nov 8, 1988·Brain Research·B A Stein, R M Sapolsky
Sep 1, 1982·The American Journal of Physiology·N D Horseman, C F Ehret
Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·S M AndersonE B De Souza
Apr 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J BoryczJ Bugajski
Feb 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M MarinelliP V Piazza
Jan 3, 2001·Medical Hypotheses·G KatzH Y Knobler
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Anne CaufriezGeorges Copinschi
Oct 12, 2002·Journal of Biological Rhythms·L WeibelO Van Reeth
Mar 25, 2004·Journal of Biological Rhythms·Dominique SageDenis Becquet

❮ Previous
Next ❯

Citations

Jan 29, 2014·Neuroscience and Biobehavioral Reviews·Erin L ZelinskiRobert J McDonald
Jun 26, 2010·The Journal of Clinical Investigation·Silke KiesslingHenrik Oster
Aug 16, 2012·Endocrinology·Pinar PezükMichael Menaker
Jun 28, 2012·Chronobiology International·Yuval WeiglIsrael E Ashkenazi
Dec 26, 2013·General and Comparative Endocrinology·Rene QuispeRodrigo A Vasquez
Apr 27, 2005·Journal of Biological Rhythms·Jennifer A Mohawk, Theresa M Lee
Jul 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tammy J JechuraTheresa M Lee
Sep 1, 2011·Expert Review of Endocrinology & Metabolism·Johanna BarclayHenrik Oster
Feb 14, 2012·Journal of Mammalogy·Loren D HayesLuis A Ebensperger
May 20, 2017·Annual Review of Neuroscience·Lorenzo Lazzerini OspriSamer Hattar
Dec 22, 2019·Journal of Molecular Biology·Urs Albrecht
Mar 17, 2018·General and Comparative Endocrinology·Carolyn M BauerL Michael Romero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.