Inhibiting endogenous cortisol blunts the meal-entrained rise in serum leptin

The Journal of Clinical Endocrinology and Metabolism
B LaferrèreColleen D Russell

Abstract

Administration of glucocorticoids increases serum leptin levels in lean and obese individuals. A morning meal produces an increase in insulin, a cortisol peak, and an increase in leptin; these changes do not occur during fasting. The objective of this study was to investigate whether inhibiting endogenous cortisol secretion with metyrapone decreases 24-h serum leptin levels and to determine whether a meal-related midmorning surge in cortisol is a prerequisite for the meal-entrained nocturnal rise in leptin. This was a randomized, cross-over study. The study was performed at the General Clinical Research Center. Lean males were studied. In study 1, seven lean men were studied for 24 h while their endogenous cortisol secretions were manipulated as follows: 1) CONTROL; 2) cortisol suppression by metyrapone (MET); and 3) MET and oral hydrocortisone (at 0900 h) (MET + CORT). Subjects were all fed a eucaloric diet (two meals at 1100 and 1700 h). In study 2, six men were studied without pharmacological intervention for 24 h on two occasions: once under a complete fast (FAST) and once in a feeding condition (one meal at 1100 h; FED). The main outcome measure was serum leptin. MET significantly suppressed serum cortisol at 0800 h, midmo...Continue Reading

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Citations

Jul 9, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Mousumi BoseBlandine Laferrère
Jun 5, 2007·Physiology & Behavior·Tanja C Adam, Elissa S Epel
Aug 23, 2018·Journal of Biological Rhythms·Azure D GrantLance J Kriegsfeld
Jun 9, 2010·Chronobiology International·Christopher J MorrisGreg Atkinson
Nov 24, 2006·American Journal of Physiology. Endocrinology and Metabolism·Mi-Jeong LeeSusan K Fried
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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