Inhibiting the transient choroidal thickening response using the nitric oxide synthase inhibitor l-NAME prevents the ameliorative effects of visual experience on ocular growth in two different visual paradigms

Experimental Eye Research
Debora L NicklaJames R Mertz

Abstract

It is generally accepted that the increase in choroidal thickness in response to myopic defocus in chicks acts to move the retina towards the image plane. It may also constitute part of the signal cascade in the visual regulation of eye growth. To test this, we used the nitric oxide synthase inhibitor l-NAME to inhibit the defocus induced choroidal thickening under two different visual conditions, and looked at the effects on ocular growth rate. Exp. 1: Deprivation/Vision: chicks were monocularly deprived of form vision with translucent diffusers from day 6 to day 9. In the middle of each day the diffusers were removed for 2 h. One group received an intravitreal injection of 30 microl l-NAME (16 micromole; n=12) prior to the vision, a second group received injections of physiological saline (n=11). Exp. 2: Recovery/Vision: chicks were made myopic by form deprivation from day 6 to day 10. On days 11 to 14 the diffusers were removed for 2 h per day for 4 days to allow eyes to "recover" from the myopia. One group received an injection of l-NAME prior to vision (n=8), the other saline (n=6). Refractive errors were measured with a refractometer at the start (days 6 and 11) and end (days 10 and 15, respectively) of both experiments. ...Continue Reading

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Citations

Jun 19, 2013·Documenta Ophthalmologica. Advances in Ophthalmology·Rachel M GriffithJames D Akula
Apr 30, 2015·Oxidative Medicine and Cellular Longevity·Bosch-Morell FranciscoNavea Amparo
Jun 6, 2013·International Journal of Endocrinology·Maurice DungeyNicolette C Bishop
Jan 2, 2010·Progress in Retinal and Eye Research·Debora L Nickla, Josh Wallman
May 15, 2013·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Debora L NicklaJosh Wallman
Mar 23, 2011·British Journal of Pharmacology·Melanie J MurphySheila G Crewther
Mar 9, 2013·Experimental Eye Research·Xiaoying Zhu
Apr 20, 2014·Experimental Eye Research·Li HeThomas T Norton
Oct 8, 2016·Scientific Reports·Zhengwei ZhangZhifeng Wu
Jul 6, 2014·Journal of Child Neurology·Marcella NebbiosoNicola Pescosolido
Mar 1, 2019·Investigative Ophthalmology & Visual Science·David TroiloLyndon Jones
Aug 26, 2020·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Liyang TongJunwen Zeng
Jun 2, 2020·Frontiers in Physiology·Salvador MéridaFrancisco Bosch-Morell
Apr 27, 2017·Scientific Reports·Brittany J Carr, William K Stell
Dec 16, 2020·Investigative Ophthalmology & Visual Science·Luyao YeXun Xu
Dec 19, 2020·European Journal of Ophthalmology·Ceylan Uslu Dogan, Damla Culha
Jun 26, 2021·Microvascular Research·Ting YuHongsheng Bi
Oct 6, 2021·ELife·Jody A Summers, Elizabeth Martinez

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