Inhibition activity of wild berry juice fractions against Streptococcus pneumoniae binding to human bronchial cells

Phytotherapy Research : PTR
Sanna HuttunenCarina Tikkanen-Kaukanen

Abstract

Bacterial adhesion to the cell surface is a crucial step before infection can take place. Inhibition of bacterial binding offers a novel preventive approach against infections. Cranberry (Vaccinium macrocarpon Ait.) juice has been found to have antiadhesive activity against different bacteria. Streptococcus pneumoniae is an important pathogen and the most common cause for pneumonia, meningitis, and otitis media. In this study the inhibitory activity of cranberry (Vaccinium oxycoccos L.), bilberry (Vaccinium myrtillus L.) and crowberry (Empetrum nigrum and Empetrum hermaphroditum L.) juice fractions against pneumococcal binding was tested using human bronchial cells (Calu-3) as an adhesion model. In addition, the antimicrobial activity of the berry juice fractions was tested. It was found that the studied berry juice fractions had antiadhesion activity and cranberry juice was the most active. The adhesion inhibition activity of cranberry juice was nearly 90% at a concentration of 8.7 mg/g of soluble solids. The antimicrobial activity of the studied berry juice fractions was found to be remarkable; pneumococcal growth was inhibited totally at a concentration of ∼86 mg/g. Both antiadhesion and antimicrobial activities were reduced...Continue Reading

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Citations

Jan 14, 2016·BMC Research Notes·Sanna HuttunenCarina Tikkanen-Kaukanen
Dec 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tunde JurikovaDaniela Sumczynski
Jan 3, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sanna HuttunenCarina Tikkanen-Kaukanen
Dec 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tunde JurikovaLukas Snopek
May 6, 2021·Natural Product Research·Anastasiia O PonkratovaVladimir G Luzhanin

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