Inhibition by 5-hydroxytryptamine of anaphylactic histamine release from bovine granulocytes

European Journal of Pharmacology
M C Holroyde, P Eyre

Abstract

A suspension of granulocytes from calves sensitised to horse plasma released histamine when exposed to the antigen. Histamine release was strongly inhibited by 5-hydroxytryptamine in a dose-related fashion. 5-HT is known to be released from bovine lungs in vitro, and may regulate the release of histamine in vivo during anaphylaxis.

References

Jun 1, 1972·Canadian Journal of Physiology and Pharmacology·A J Lewis, P Eyre
Sep 1, 1972·The Journal of Experimental Medicine·M KalinerK F Austen
Apr 5, 1974·Science·H R BourneG M Shearer
Mar 1, 1973·British Journal of Pharmacology·P EyreP W Wells
Jan 1, 1968·International Archives of Allergy and Applied Immunology·M W Greaves, B D Burdis
Dec 1, 1974·Canadian Journal of Physiology and Pharmacology·L M Stotland, N N Share
Feb 18, 1965·Nordisk medicin·C B CHRISTENSEN, J SCHOU

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Citations

Jan 1, 1994·Transplant Immunology·W HongweiA D Hibberd
Dec 1, 1977·British Journal of Pharmacology·H W Mitchell, M P Sparrow

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.