Jun 1, 1976

Inhibition by 5-hydroxytryptamine of anaphylactic histamine release from bovine granulocytes

European Journal of Pharmacology
M C Holroyde, P Eyre

Abstract

A suspension of granulocytes from calves sensitised to horse plasma released histamine when exposed to the antigen. Histamine release was strongly inhibited by 5-hydroxytryptamine in a dose-related fashion. 5-HT is known to be released from bovine lungs in vitro, and may regulate the release of histamine in vivo during anaphylaxis.

  • References10
  • Citations4

References

Mentioned in this Paper

Histamine Measurement
Anaphylaxis (Non Medication)
Depression, Chemical
Lung
Serotonin
Granulocyte Count
Bos taurus
Equus caballus
Leukocytes
Antigens

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.