Inhibition by antipsychotic drugs of L-type Ca2+ channel current in PC12 cells

European Journal of Pharmacology
K ItoK Inoue

Abstract

Inhibition by antipsychotic drugs of voltage-gated L-type Ca2+ channels was characterized in rat neuronal cell line pheochromocytoma PC12 cells. Under whole-cell voltage-clamp, haloperidol and chlorpromazine (1-100 microM) inhibited Ba2+ current permeating through Ca2+ channels. Fluspirilene and pimozide the Ba2+ current at lower concentrations (fluspirilene, 0.1 pM to 1 nM; pimozide 10 pM to 1 microM). Effects of dopamine receptor antagonists and calmodulin antagonists were tested because antipsychotic drugs are known to exhibit these pharmacological activities. Sulpiride (1 and 10 microM), an antagonist to dopamine D2 receptors, and SCH-23390 (R(+)-7-chloro-8-hydroxy-3-methyl-l-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepine; 1 and 10 microM), an antagonist to dopamine D1 receptors, also inhibited the Ba2+ current. As for calmodulin antagonists, W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide; 10 and 100 microM) as well as calmidazolium (10 nM to 1 microM) reduced the Ba2+ current. The inhibition by haloperidol or fluspirilene of the Ba2+ current was not affected when GTP in intracellular solution was replaced with GDP beta S. These properties of the Ca2+ channel inhibition are discussed by comparing with those of the K+ ...Continue Reading

References

Jan 1, 1990·Annual Review of Neuroscience·P Hess
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J P GalizziM Lazdunski
Jan 1, 1989·Annual Review of Physiology·B P Bean
Oct 1, 1973·Canadian Psychiatric Association Journal·A N Singh
Jan 12, 1980·British Medical Journal·T J Crow
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R J GouldS H Snyder
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Jul 30, 1981·Biochemical and Biophysical Research Communications·K GietzenH Bader
Apr 1, 1995·Trends in Pharmacological Sciences·M SpeddingP Chatelain
Feb 1, 1994·British Journal of Pharmacology·C J GranthamM B Cannell
Apr 15, 1994·European Journal of Pharmacology·E J FletcherJ F MacDonald
Dec 29, 1995·European Journal of Pharmacology·L Antkiewicz-MichalukJ Vetulani

❮ Previous
Next ❯

Citations

Aug 6, 2000·Biochemical Pharmacology·A Szewczyk, S Pikula
Jun 16, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·D S DwyerR J Bradley
Jul 31, 2012·Cardiovascular Research·Osamu YamaguchiKinya Otsu
Dec 22, 1999·The Japanese Journal of Physiology·H IshidaH Nakazawa
Jan 15, 2009·Canadian Journal of Physiology and Pharmacology·Lars Jørn Jensen, Niels-Henrik Holstein-Rathlou
Dec 12, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Carmen TeodorescuSumeet S Chugh
Mar 2, 2006·Journal of Pharmacological and Toxicological Methods·Hsien C ChengBruce McCullough
Jun 26, 2013·European Journal of Pharmacology·Anjana BaliAmteshwar Singh Jaggi
May 31, 2014·Biochemical and Biophysical Research Communications·Weiqiang ChenKangsheng Li
Dec 18, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Su-Hyun Jo, So-Young Lee
Oct 8, 1999·Journal of Cardiovascular Pharmacology·M SunagawaN Sperelakis
Mar 26, 1998·Biochemical and Biophysical Research Communications·S KoizumiK Inoue

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here