PMID: 2118334Sep 1, 1990Paper

Inhibition by capsaicin of NADH-quinone oxidoreductases is correlated with the presence of energy-coupling site 1 in various organisms

Archives of Biochemistry and Biophysics
T Yagi

Abstract

The NADH-ubiquinone reductase activity of the respiratory chains of several organisms was inhibited by capsaicin and dihydrocapsaicin, which are the pungent principles of red pepper. This inhibition was correlated with the presence of an energy transducing site in this segment of the respiratory chain. Where the NADH-quinone oxidoreductase segment involved an energy coupling site (e.g., in Paracoccus denitrificans, Escherichia coli, and Thermus thermophilus HB-8 membranes and bovine heart mitochondria), capsaicin acted as an inhibitor of ubiquinone reduction by NADH. In contrast, where this energy coupling site was absent (e.g., in Saccharomyces cerevisiae mitochondria and Bacillus subtilis membranes), there was no inhibition of NADH-ubiquinone reductase activity by capsaicin. The capsaicin inhibition of Paracoccus membranes was reversed by washing the membranes with medium containing bovine serum albumin. In the E. coli and Paracoccus membranes and bovine submitochondrial particles, capsaicin acted as a noncompetitive inhibitor for ubiquinone-1 at lower concentrations of ubiquinone-1 (less than 20 microM) and as a competitive inhibitor at higher concentrations of ubiquinone-1 (greater than 50 microM). In addition, the concentr...Continue Reading

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Citations

Dec 18, 2001·Journal of Applied Toxicology : JAT·E J Olajos, H Salem
Apr 1, 1991·Journal of Bioenergetics and Biomembranes·T Yagi
Sep 1, 2005·Apoptosis : an International Journal on Programmed Cell Death·N Hail
Mar 13, 1992·Biochimica Et Biophysica Acta·W OettmeierM Soll
Jun 19, 1998·Biochimica Et Biophysica Acta·T YagiA Matsuno-Yagi
Dec 21, 2010·Biochemistry. Biokhimii︠a︡·K A KegyarikovaA D Vinogradov
Jan 8, 1999·Biochimica Et Biophysica Acta·A V UshakovaA D Vinogradov
Jun 5, 2004·Biochimica Et Biophysica Acta·Patries M HerstMichael V Berridge
Dec 21, 2004·Journal of Biochemistry and Molecular Biology·Man Suk Kim, Young Jae Kim
Jan 25, 2007·Journal of Biochemistry and Molecular Biology·Jiwon Kang, Young Jae Kim
Dec 9, 2008·Biochimica Et Biophysica Acta·Romana FatoGiorgio Lenaz
Sep 8, 2010·Biophysical Journal·Xuewen ChenDaniel A Beard
Jul 17, 1992·Biochimica Et Biophysica Acta·T YagiA Matsuno-Yagi
Jun 27, 1997·The Journal of Biological Chemistry·H MiyoshiH Iwamura
May 25, 2004·The Journal of Biological Chemistry·Eva C VaqueroAnna S Gukovskaya
Aug 10, 2006·The Journal of Clinical Endocrinology and Metabolism·R John AitkenEileen A McLaughlin
Nov 17, 2019·Applied and Environmental Microbiology·Catharine A AdamsAnne Pringle
Aug 1, 1992·Quarterly Reviews of Biophysics·J E Walker

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