PMID: 8584045Sep 1, 1995Paper

Inhibition by carbamazepine of various ion channels-mediated catecholamine secretion in cultured bovine adrenal medullary cells

Naunyn-Schmiedeberg's Archives of Pharmacology
R YoshimuraF Izumi

Abstract

The effects of carbamazepine (CBZ) on 22Na+ influx, 45Ca2- influx, catecholamine secretion and cyclic GMP production were examined in cultured bovine adrenal medullary cells. 1) CBZ (40-120 mumol/l) inhibited 22Na+ influx evoked by carbachol in a concentration-dependent manner. CBZ inhibited carbachol-evoked 45Ca2- influx and catecholamine secretion at concentrations similar to those which suppressed 22Na+ influx. 2) CBZ (4-120 mumol/l) inhibited veratridine-induced 22Na+ influx, 45Ca2+ influx and catecholamine secretion. 3) CBZ (12 or 40-120 mumol/l) suppressed 56 mmol/l K(+)-evoked 45Ca2+ influx and catecholamine secretion, respectively. 4) Combination of CBZ with nitrendipine or omega-agatoxin-IVA produced further inhibition of 56 mmol/l K(+)-evoked 45Ca2+ influx and catecholamine secretion, compared to the effect of CBZ alone, whereas CBZ plus omega-conotoxin-GVIA did not produce any further inhibition. 5) CBZ (40 mumol/l) attenuated the production of cyclic GMP caused by muscarine. These results suggest that CBZ at therapeutic concentrations (16-48 mumol/l; 4-12 micrograms/ml) inhibits catecholamine secretion by interfering with nicotinic acetylcholine receptor-associated ion channels, voltage-dependent Na+ channels and N-...Continue Reading

Citations

Oct 6, 2001·Pediatric Neurology·A Di Martino, R F Tuchman
Jun 23, 2000·Epilepsy Research·K MizunoS Kaneko
Aug 29, 1998·Epilepsy Research·M OkadaS Kaneko
Nov 14, 2002·British Journal of Pharmacology·Ran-Sook WooKee-Won Kim
Nov 9, 2002·Epilepsia·Rüdiger Köhling
May 7, 2002·Journal of Toxicology. Clinical Toxicology·Henry A Spiller, Richard D Carlisle
Oct 22, 2002·Expert Opinion on Pharmacotherapy·Nanna B FinnerupTroels S Jensen
Dec 4, 2003·Progress in Brain Research·Ortrud K Steinlein
Jul 25, 2006·The International Journal of Neuroscience·Mousa SahebgharaniM R Zarrindast
Dec 26, 2001·Pediatric Emergency Care·H A Spiller
Jan 31, 2020·Current Treatment Options in Neurology·Gian Maria AsioliFederica Provini

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