PMID: 3770128Nov 1, 1986Paper

Inhibition by corticosterone of paraventricular nucleus multiple-unit activity responses to sensory stimuli in freely moving rats

Experimental Neurology
G MorS Feldman

Abstract

In order to determine possible electrophysiologic correlates of negative feedback influences of glucocorticoids upon neuroendocrine secretory activity, the effects of various doses of corticosterone on paraventricular nucleus multiple-unit activity responses to neural stimuli were examined in conscious, freely moving male rats. In control animals, photic and acoustic stimulation significantly increased multiple-unit activity of the paraventricular nucleus by increments of 75% and 117% (P less than 0.005), respectively. Doses between 0.1 and 5.0 mg of corticosterone produced a dose-dependent inhibition of responses to photic stimulation with a high correlation coefficient (r = -0.990). Corticosterone also caused an inhibition of paraventricular multiple-unit activity in response to acoustic stimulation, which was more effective than for photic stimulation, with complete blockade of response occurring with a dose of 1 mg corticosterone. These electrophysiologic findings, within a region of the hypothalamus known to contain corticotrophin-releasing factor cell bodies, may be related to reduced secretion of the hormone in response to the neurogenic stimuli employed, following glucocorticoid administration.

Citations

Apr 27, 2004·Neuroreport·Morten P KristensenRonald M Harper
Dec 1, 1991·Journal of Neuroendocrinology·D M Hayden-Hixson, C F Ferris
Feb 26, 2010·Molecular Brain·Therese RiedemannOsborne F X Almeida
Dec 15, 2010·The European Journal of Neuroscience·Jaclyn I Wamsteeker, Jaideep S Bains
Jan 24, 2015·Journal of Neuroendocrinology·J I Wamsteeker Cusulin, J S Bains
Mar 18, 2021·Neuroscience and Biobehavioral Reviews·Aneta Jaszczyk, Grzegorz R Juszczak
Oct 26, 2005·Frontiers in Neuroendocrinology·Mary F Dallman

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