Inhibition by ethanol of excitatory amino acid receptors and nicotinic acetylcholine receptors at rat locus coeruleus neurons

Naunyn-Schmiedeberg's Archives of Pharmacology
R FröhlichP Illes

Abstract

The frequency of spontaneous action potentials of locus coeruleus (LC) neurons was recorded extracellularly in pontine slices of the rat brain. Ethanol (1-100 mM) elevated the firing rate in most neurons; this effect was concentration-dependent. (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA; 0.03-1 microM), kainate (0.1-3 microM), N-methyl-D-aspartate (NMDA; 1-30 microM), substance P (0.01-1 microM), nicotine (0.1-10 microM) and alpha,beta-methylene ATP (alpha,beta-meATP; 0.3-30 microM), all increased the firing. Application of ethanol (10-100 mM) to the superfusion medium for 10 min, reproducibly and concentration-dependently inhibited the facilitatory effect of NMDA (10 microM). However, the inhibitory effect of ethanol (100 mM) decreased during a 30-min superfusion period and after the wash-out of ethanol the sensitivity of LC neurons to NMDA (10 microM) tended to overshoot above their initial level. Although NMDA was more potent in the absence than in the presence of external Mg2+, ethanol (100 mM) continued to depress the facilitatory effect of a low concentration of NMDA (3 microM) in a Mg(2+)-free medium. By contrast, in a medium containing normal Mg2+, ethanol (100 mM) failed to significantly interf...Continue Reading

Citations

Nov 21, 1996·European Journal of Pharmacology·R FröhlichP Illes
Apr 4, 1998·European Journal of Pharmacology·M NavamaniR J Williams
Jan 4, 1998·Pharmacology, Biochemistry, and Behavior·P BienkowskiW Kostowski
Jun 4, 1998·Pharmacology, Biochemistry, and Behavior·P Bienkowski, W Kostowski
Aug 15, 2000·Behavioural Brain Research·B SöderpalmJ A Engel
Sep 6, 2002·Neurochemistry International·C Allgaier
Jul 16, 1999·Neurochemistry International·K WirknerP Illes
Jul 22, 1998·Progress in Neurobiology·C L FaingoldA Riaz
May 15, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jens M LangoschJ Walden
Jun 10, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P BienkowskiW Kostowski
Jan 10, 1998·British Journal of Pharmacology·P J Covernton, J G Connolly
Aug 21, 2007·Biochemical Pharmacology·Justin T Gass, M Foster Olive
Feb 10, 2007·Brain Research·Hua-Jun FengCarl L Faingold

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