PMID: 9550302Apr 29, 1998Paper

Inhibition by ethanol of excitatory amino acid receptors in rat locus coeruleus neurons in vitro

Naunyn-Schmiedeberg's Archives of Pharmacology
K NieberP Illes

Abstract

Intracellular recordings were made in a pontine slice preparation of the rat brain containing the nucleus locus coeruleus (LC). In a first series of experiments, various parameters of spontaneous action potentials were evaluated. It turned out that ethanol (100 mM) does not alter the firing rate, the spike amplitude and the afterhyperpolarization following a spike. In subsequent experiments, the generation of action potentials was prevented by passing continuous hyperpolarizing current via the recording electrode. Under these conditions, ethanol (100 mM) had no effect on the membrane potential or input resistance. Pressure-applied N-methyl-D-aspartate (NMDA), (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and alpha,beta-methylene ATP (alpha,beta-meATP) reproducibly depolarized LC neurons. While ethanol (100 mM) depressed the NMDA- and AMPA-induced depolarization to a similar extent, it did not interact with alpha,beta-meATP. Lower concentrations of ethanol (10 and 30 mM) had no effect on depolarizing responses to NMDA or AMPA. Noradrenaline applied by pressure pulses reproducibly hyperpolarized LC cells. These hyperpolarizations were unchanged by ethanol (100 mM). Biphasic synaptic potentials consisting of ...Continue Reading

Citations

Jan 17, 2007·Psychopharmacology·Karen K SzumlinskiM Scott Bowers
Sep 6, 2002·Neurochemistry International·C Allgaier
Jul 16, 1999·Neurochemistry International·K WirknerP Illes
Mar 2, 1999·British Journal of Pharmacology·C AllgaierP Illes
Apr 26, 2000·British Journal of Pharmacology·H J LittleW P Watson
Dec 24, 2003·Alcoholism, Clinical and Experimental Research·B Emmanuel AkinsholaRobert E Taylor
Mar 22, 2012·Alcoholism, Clinical and Experimental Research·Debra K CozzoliKaren K Szumlinski
Aug 21, 2007·Biochemical Pharmacology·Justin T Gass, M Foster Olive
Feb 10, 2007·Brain Research·Hua-Jun FengCarl L Faingold

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