PMID: 9539309Apr 16, 1998Paper

Inhibition by gonadotropins of interleukin-1 production by rabbit granulosa and theca cells: effects on gonadotropin-induced progesterone production

European Journal of Endocrinology
E BréardP Leymarie

Abstract

Increasing evidence suggests that cytokines may play a role in ovarian processes. The purpose of this study was to determine if interleukin-1 (IL-1) could modulate rabbit pre-ovulatory follicular function and to explore cellular sites of IL-1 biosynthesis in rabbit follicles. Development of rabbit pre-ovulatory follicles was induced by 200 mIU equine chorionic gonadotropin daily for 2 days. Seventy-two hours after the last injection, ovaries were excised and granulosa and theca cells isolated. The two types of cell were pre-incubated for 24 h in Minimum Essential Medium (MEM) with 5% fetal calf serum (FCS), and then incubated for 24 h in MEM with 2.5% FCS with appropriate stimulants. Results showed that rabbit granulosa and theca cell culture supernatants contain IL-1 bioactivity and that this bioactivity was diminished by gonadotropins, FSH and human chorionic gonadotropin, in a dose-dependent manner. Low doses of IL-1 (1 ng/ml) inhibited gonadotropin-induced progesterone production in both cell types and at the same time increased cell numbers. A study of the mechanism of IL-1 action demonstrated that it affects cAMP generation, and also steps distal to cAMP formation. We conclude that in our model gonadotropins, by inhibitin...Continue Reading

Citations

Jun 14, 2003·Reproductive Biology and Endocrinology : RB&E·Alain Martoriati, Nadine Gérard
Aug 19, 2007·Developmental and Comparative Immunology·N R SundaresanK A Ahmed
Jul 25, 2006·Journal of Reproductive Immunology·N R SundaresanK A Ahmed
Oct 31, 2009·Immunopharmacology and Immunotoxicology·Annalisa RizzoRaffaele Luigi Sciorsci
Jun 9, 2005·The Journal of Clinical Endocrinology and Metabolism·W Colin DuncanHamish M Fraser
Jan 29, 2021·Animals : an Open Access Journal From MDPI·Massimo ZeraniMargherita Maranesi
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Margherita MaranesiMassimo Zerani

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