PMID: 6538491Feb 1, 1984Paper

Inhibition by hydroxy-N-methyl elliptinium of precancerous mammary hyperplastic alveolar nodule formation in mice

European Journal of Cancer & Clinical Oncology
H NagasawaK Niki

Abstract

Daily subcutaneous injections of 5 micrograms hydroxy-N-methyl elliptinium for 4 weeks in a high mammary tumor strain of SHN virgin mice was found to decrease the number of precancerous mammary hyperplastic alveolar nodules (HAN) associated with the increase in the number of ghosts, the remnants of regressed HAN. On the other hand, the treatment had little influence on the normal mammary lobulo-alveolar system, serum prolactin level, estrous cycle and endocrine organ weights. The results have demonstrated that elliptinium can inhibit the formation of HAN and induce their regression with no modulation of endogenous conditions of mammotropic hormones.

References

Feb 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P JuretC Paoletti
Dec 1, 1982·European Journal of Cancer & Clinical Oncology·A GouyetteJ L Amiel
Apr 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H NagasawaK Shiota

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