Inhibition by immunoglobulins of Staphylococcus aureus adherence to fibronectin-coated foreign surfaces

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
P VaudauxF A Waldvogel

Abstract

Recent data suggest that fibronectin may favor Staphylococcus aureus infection by promoting attachment to either injured tissues or implanted foreign bodies. Using a previously described in vitro assay, we show that promotion of S. aureus adherence by surface-bound fibronectin, adsorbed on polymethylmethacrylate (PMMA) coverslips, is antagonized by antistaphylococcal antibodies present in immunoglobulin G (IgG) purified from human plasma. Among the different organisms tested, the protein A-deficient strain Wood 46 of S. aureus was the most strongly inhibited by purified IgG or whole serum dose-dependently. Bacterial adherence was not influenced by preincubating fibronectin-coated PMMA with either purified IgG or whole serum. However, inhibition of bacterial adherence was directly related to the extent of IgG binding to S. aureus Wood 46. When F(ab')2 fragments of purified IgG were tested in the adherence assay, they could also reduce the interaction between S. aureus Wood 46 and fibronectin-coated PMMA. Two other staphylococcal strains were also tested in the adherence inhibition assay: Whereas the protein A-rich strain Cowan I of S. aureus was moderately inhibited by purified IgG or whole serum, S. epidermidis KH 11 was not at...Continue Reading

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Citations

May 29, 2000·Journal of Biomedical Materials Research·K A PoelstraH J Busscher
Aug 23, 2001·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·U E NydeggerP Mohacsi
Oct 2, 2007·The Journal of Thoracic and Cardiovascular Surgery·Pierre-Yves LitzlerJean-Paul Bessou
Dec 10, 1989·Transfusion Science·U E NydeggerB Aeschbacher
Sep 1, 1989·European Journal of Cancer & Clinical Oncology·D P Lew
Feb 13, 2021·BioMed Research International·Elisa SeriaAlex Felice

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