Inhibition by itaconate of growth of methylotrophic bacteria.

Journal of Bacteriology
E Bellion, R L Kelley

Abstract

The effects of the isocitrate lyase-directed growth inhibitor itaconate on the growth of certain methylotrophic organisms was investigated. It was found that growth of those organisms possessing the Icl(+)-serine pathway of one-carbon metabolism was inhibited during growth on methylamine and on acetate, but not on glucose. Organisms possessing the Icl(-)-serine pathway pathway were unaffected. Organism PAR, an Icl(-)-serine pathway type, was not specifically inhibited during growth on acetate. This finding further substantiates previous reports of the lack of isocitrate lyase in this organism, indicating a totally new pathway for acetate assimilation.

Citations

Oct 3, 1999·The Plant Journal : for Cell and Molecular Biology·M Runquist, N J Kruger
May 31, 2019·Frontiers in Microbiology·Chee Kent LimPatrick K H Lee
May 23, 2021·Microbiology·Dustin DuncanKarine Auclair
Jan 1, 1990·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·P VanniB A McFadden

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